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    SOH1 mediator complex subunit SOH1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852750, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SOH1
    Official Full Name
    mediator complex subunit SOH1
    Primary source
    SGD:S000003095
    Locus tag
    YGL127C
    See related
    AllianceGenome:SGD:S000003095; FungiDB:YGL127C; VEuPathDB:YGL127C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MED31
    Summary
    Enables transcription coactivator activity. Involved in DNA repair; meiotic gene conversion; and transcription by RNA polymerase II. Located in nucleus. Part of core mediator complex. Orthologous to human MED31 (mediator complex subunit 31). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See SOH1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (270392..270775, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein RSM23 Neighboring gene U2-type spliceosomal complex subunit CWC23 Neighboring gene Scs3p Neighboring gene methylenetetrahydrofolate reductase (NAD(P)H) MET13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence analysis of a 10 kb DNA fragment from yeast chromosome VII reveals a novel member of the DnaJ family. Rodriguez-Belmonte E, et al. Yeast, 1996 Feb. PMID 8686378
    2. The functions of Mediator in Candida albicans support a role in shaping species-specific gene expression. Uwamahoro N, et al. PLoS Genet, 2012. PMID 22496666, Free PMC Article
    3. TFIIS elongation factor and Mediator act in conjunction during transcription initiation in vivo. Guglielmi B, et al. Proc Natl Acad Sci U S A, 2007 Oct 9. PMID 17901206, Free PMC Article
    4. The Soh1/MED31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae Mediator. Linder T, et al. J Biol Chem, 2004 Nov 19. PMID 15356001
    5. Mediator subunit Gal11p/MED15 is required for fatty acid-dependent gene activation by yeast transcription factor Oaf1p. Thakur JK, et al. J Biol Chem, 2009 Feb 13. PMID 19056732, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Soh1/MED31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae Mediator
      Title: The Soh1/MED31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae Mediator.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in meiotic gene conversion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of core mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mediator complex subunit SOH1
    NP_011388.1
    • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      270392..270775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180992.1 → NP_011388.1  TPA: mediator complex subunit SOH1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011388.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU21, P38633
      UniProtKB/TrEMBL
      A6ZU55, B3LHI7, C7GX62, C8Z8C3, G2WDX5, N1P9N8
      Conserved Domains (1) summary
      COG5088
      Location:2 → 127
      SOH1; Rad5p-binding protein [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38633.1

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