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    SOR1 L-iditol 2-dehydrogenase SOR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853624, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SOR1
    Official Full Name
    L-iditol 2-dehydrogenase SOR1
    Primary source
    SGD:S000003920
    Locus tag
    YJR159W
    See related
    AllianceGenome:SGD:S000003920; FungiDB:YJR159W; VEuPathDB:YJR159W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SDH1
    Summary
    Enables L-iditol 2-dehydrogenase (NAD+) activity. Involved in hexose metabolic process. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 8. Orthologous to human SORD (sorbitol dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SOR1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (736044..737117)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase Neighboring gene hexose transporter HXT16 Neighboring gene alpha-glucoside permease Neighboring gene Cos5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and sequence determination of the gene encoding sorbitol dehydrogenase from Saccharomyces cerevisiae. Sarthy AV, et al. Gene, 1994 Mar 11. PMID 8125328
    2. Construction of a sorbitol-based vector for expression of heterologous proteins in Saccharomyces cerevisiae. McGonigal T, et al. Appl Environ Microbiol, 1998 Feb. PMID 9464424, Free PMC Article
    3. Metabolic engineering considerations for the heterologous expression of xylose-catabolic pathways in Saccharomyces cerevisiae. Jeong D, et al. PLoS One, 2020. PMID 32716960, Free PMC Article
    4. Endogenous xylose pathway in Saccharomyces cerevisiae. Toivari MH, et al. Appl Environ Microbiol, 2004 Jun. PMID 15184173, Free PMC Article
    5. Improving xylitol yield by deletion of endogenous xylitol-assimilating genes: a study of industrial Saccharomyces cerevisiae in fermentation of glucose and xylose. Yang BX, et al. FEMS Yeast Res, 2020 Dec 16. PMID 33201998

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-xylulose reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-iditol 2-dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-iditol 2-dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-iditol 2-dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-iditol 2-dehydrogenase (NAD+) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-iditol 2-dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hexose metabolic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in sorbitol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    L-iditol 2-dehydrogenase SOR1
    NP_012693.1
    • Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor2p sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      736044..737117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181817.1 → NP_012693.1  TPA: L-iditol 2-dehydrogenase SOR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012693.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWX7, P35497
      UniProtKB/TrEMBL
      A6ZX89, B3LHC1, B5VF37, C8Z6M7
      Conserved Domains (1) summary
      cd05285
      Location:8 → 353
      sorbitol_DH; Sorbitol dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35497.1

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