SSN8 cyclin-dependent protein serine/threonine kinase regulator SSN8 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: SSN8
Official Full Name: cyclin-dependent protein serine/threonine kinase regulator SSN8
Primary source: SGD:S000004970
Locus tag: YNL025C
See related: AllianceGenome:SGD:S000004970; FungiDB:YNL025C; VEuPathDB:YNL025C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CNC1; GIG3; NUT9; RYE2; SRB11; UME3
Summary: Enables RNA polymerase II core promoter sequence-specific DNA binding activity and cyclin-dependent protein serine/threonine kinase regulator activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription by galactose; and positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle. Part of mediator complex. Orthologous to human CCNC (cyclin C). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Role of CNC1 gene in TDP-43 aggregation-induced oxidative stress-mediated cell death in S. cerevisiae model of ALS.
Title: Role of CNC1 gene in TDP-43 aggregation-induced oxidative stress-mediated cell death in S. cerevisiae model of ALS.
Releasing cyclin C from the nucleus involves both its phosphorylation by Slt2p coupled with Med13p destruction.
Title: Med13p prevents mitochondrial fission and programmed cell death in yeast through nuclear retention of cyclin C.
Srb8-Srb11 associates with the GAL1 promoter subsequent to SAGA binding, and the binding of TBP and Srb8-Srb11 is interdependent
Title: The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcription.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA polymerase II core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by galactose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

Preferred Names: cyclin-dependent protein serine/threonine kinase regulator SSN8

NP_014373.3

Cyclin-like component of RNA polymerase II holoenzyme; involved in phosphorylation of RNAPII C-terminal domain; forms kinase-cyclin pair in RNAPII holoenzyme with Ssn3p; needed for entry into and execution of meiotic program; involved in glucose repression, telomere maintenance; degraded in response to nitrogen starvation, and also to oxidative stress, but in different cellular compartments, and with different cellular outcomes; 35% identical to human cyclin C

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