TDH1 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TDH1
Official Full Name: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1
Primary source: SGD:S000003588
Locus tag: YJL052W
See related: AllianceGenome:SGD:S000003588; FungiDB:YJL052W; VEuPathDB:YJL052W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GLD3
Summary: Enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity and melatonin binding activity. Involved in gluconeogenesis and glycolytic process. Located in several cellular components, including fungal-type cell wall; lipid droplet; and mitochondrion. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to several human genes including GAPDH (glyceraldehyde-3-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See TDH1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (338271..339269)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of the GAPDH gene contributes to genome stability in Saccharomyces cerevisiae.
Title: Deletion of the GAPDH gene contributes to genome stability in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	IDA Inferred from Direct Assay more info	PubMed
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	IEA Inferred from Electronic Annotation more info
enables melatonin binding	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in gluconeogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in external encapsulating structure	IEA Inferred from Electronic Annotation more info
located_in fungal-type cell wall	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IPI Inferred from Physical Interaction more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1

NP_012483.3

EC 1.2.1.12

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bacteria

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

338271..339269

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181485.3 → NP_012483.3 TPA: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012483.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWD1, P00360

UniProtKB/TrEMBL

A6ZPS3, B3LQ59, C8ZBG2, G2WGW5, N1NZW1

Conserved Domains (1) summary

PLN02272
Location:2 → 330

PLN02272; glyceraldehyde-3-phosphate dehydrogenase