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    TEF2 translation elongation factor EF-1 alpha [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852415, updated on 29-Jun-2024

    Summary

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    Gene symbol
    TEF2
    Gene description
    translation elongation factor EF-1 alpha
    Primary source
    FungiDB:YBR118W
    Locus tag
    YBR118W
    See related
    SGD:S000000322; AllianceGenome:SGD:S000000322; VEuPathDB:YBR118W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables several functions, including guanyl ribonucleotide binding activity; melatonin binding activity; and small GTPase binding activity. Involved in actin filament bundle assembly; tRNA export from nucleus; and translational elongation. Located in fungal-type vacuole membrane and mitochondrion. Used to study dilated cardiomyopathy and epilepsy. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TEF2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (477671..479047)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene L-aminoadipate-semialdehyde dehydrogenase Neighboring gene transketolase TKL2 Neighboring gene Mud1p Neighboring gene Cbp6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Damaging de novo missense variants in EEF1A2 lead to a developmental and degenerative epileptic-dyskinetic encephalopathy. Carvill GL, et al. Hum Mutat, 2020 Jul. PMID 32196822, Free PMC Article
    2. Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A. Jank T, et al. J Biol Chem, 2017 Sep 29. PMID 28801462, Free PMC Article
    3. Eukaryotic translation elongation factor 1A (eEF1A) domain I from S. cerevisiae is required but not sufficient for inter-species complementation. Eltschinger S, et al. PLoS One, 2012. PMID 22860115, Free PMC Article
    4. A novel post-translational modification of yeast elongation factor 1A. Methylesterification at the C terminus. Zobel-Thropp P, et al. J Biol Chem, 2000 Nov 24. PMID 10973948
    5. Site-directed mutagenesis of yeast eEF1A. Viable mutants with altered nucleotide specificity. Cavallius J, et al. J Biol Chem, 1998 Oct 30. PMID 9786872

    See all (178) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutational analysis reveals potential phosphorylation sites in eukaryotic elongation factor 1A that are important for its activity.
      Title: Mutational analysis reveals potential phosphorylation sites in eukaryotic elongation factor 1A that are important for its activity.
    2. the Rho1p-eEF1A complex acts to spatially localize a pool of eEF1A to vacuoles where it can readily organize F-actin.
      Title: Yeast translation elongation factor-1A binds vacuole-localized Rho1p to facilitate membrane integrity through F-actin remodeling.
    3. Elongation factor 1A (EF-1A) competes with the RTD pathway for substrate tRNAs, since its overexpression suppresses the tRNA degradation and the growth defect of strains subject to RTD, whereas reduced levels of EF-1A have the opposite effect.
      Title: The yeast rapid tRNA decay pathway competes with elongation factor 1A for substrate tRNAs and acts on tRNAs lacking one or more of several modifications.
    4. The actin bundling activity of eukaryotic translation elongation factor 1A is not required for protein synthesis functions but is essential for cytoskeletal integrity. [eEF1A]
      Title: Translation elongation factor 1A is essential for regulation of the actin cytoskeleton and cell morphology.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    translation elongation factor EF-1 alpha
    NP_009676.1
    • Translational elongation factor EF-1 alpha; GTP-bound active form, binds to and delivers aminoacylated tRNA to the A-site of ribosomes for elongation of nascent polypeptides; moonlighting function as an actin binding and bundling protein; association with GTPase Rho1p on the vacuolar membrane may facilitate F-actin remodeling; involved in tRNA re-export from the nucleus; Tef2p-RFP levels increase during replicative aging

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      477671..479047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178466.1 → NP_009676.1  TPA: translation elongation factor EF-1 alpha [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009676.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQB6, P02994, Q7Z7U8, Q7Z8Q8, Q7Z8Q9
      UniProtKB/TrEMBL
      A0A6A5Q4X1, A6ZL63, B3LK50, B5VTM5, C7GPS3, C8ZJA5, G2WPQ0, N1P8G0
      Conserved Domains (1) summary
      PTZ00141
      Location:1 → 443
      PTZ00141; elongation factor 1- alpha; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02994.1

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Miscellaneous