TIM13 protein translocase subunit TIM13 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TIM13
Official Full Name: protein translocase subunit TIM13
Primary source: SGD:S000003413
Locus tag: YGR181W
See related: AllianceGenome:SGD:S000003413; FungiDB:YGR181W; VEuPathDB:YGR181W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein transporter activity. Involved in protein insertion into mitochondrial inner membrane. Located in mitochondrial intermembrane space. Part of mitochondrial intermembrane space protein transporter complex. Used to study deafness-dystonia-optic neuronopathy syndrome. Orthologous to human TIMM13 (translocase of inner mitochondrial membrane 13). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TIM13 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (858287..858604)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sudies demonstrate that Mia40, Erv1, and oxygen are the minimal machinery for Tim13 oxidation.
Title: Reconstitution of the mia40-erv1 oxidative folding pathway for the small tim proteins.
The central region of Tim23, which enters the intermembrane space first, may serve to nucleate the binding of the Tim8-Tim13 complex, thereby initiating the chaperoned translocation of Tim23 to the mitochondrial inner membrane.
Title: The Tim8-Tim13 complex has multiple substrate binding sites and binds cooperatively to Tim23.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in protein insertion into mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in protein insertion into mitochondrial inner membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
part_of mitochondrial intermembrane space protein transporter complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial intermembrane space protein transporter complex	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial intermembrane space protein transporter complex	IEA Inferred from Electronic Annotation more info
part_of mitochondrial intermembrane space protein transporter complex	IPI Inferred from Physical Interaction more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein translocase subunit TIM13

NP_011697.3

Mitochondrial intermembrane space protein; forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

858287..858604

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181310.3 → NP_011697.3 TPA: protein translocase subunit TIM13 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011697.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUW5, P53299

UniProtKB/TrEMBL

A6ZUJ3, B3LI50, C7GVV8, C8Z976, G2WER1, N1P2G4

Conserved Domains (1) summary

pfam02953
Location:35 → 92

zf-Tim10_DDP; Tim10/DDP family zinc finger