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    TOM7 Tom7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855654, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TOM7
    Official Full Name
    Tom7p
    Primary source
    SGD:S000005014
    Locus tag
    YNL070W
    See related
    AllianceGenome:SGD:S000005014; FungiDB:YNL070W; VEuPathDB:YNL070W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MOM7; YOK22
    Summary
    Contributes to protein transmembrane transporter activity. Involved in protein import into mitochondrial matrix and protein insertion into mitochondrial outer membrane. Located in mitochondrial outer membrane. Part of mitochondrial outer membrane translocase complex. Orthologous to human TOMM7 (translocase of outer mitochondrial membrane 7). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TOM7 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (493366..493548)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ribonuclease H2 catalytic subunit RNH201 Neighboring gene dihydrolipoyllysine-residue acetyltransferase Neighboring gene ribosomal 60S subunit protein L16B Neighboring gene forkhead family transcription factor FKH2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial protein import. Requirement of presequence elements and tom components for precursor binding to the TOM complex. Esaki M, et al. J Biol Chem, 2004 Oct 29. PMID 15337763
    2. A conserved proline residue is present in the transmembrane-spanning domain of Tom7 and other tail-anchored protein subunits of the TOM translocase. Allen R, et al. FEBS Lett, 2002 Mar 13. PMID 11943179
    3. Genetic and functional interactions between the mitochondrial outer membrane proteins Tom6 and Sam37. Dukanovic J, et al. Mol Cell Biol, 2009 Nov. PMID 19797086, Free PMC Article
    4. Molecular pathway of mitochondrial preprotein import through the TOM-TIM23 supercomplex. Zhou X, et al. Nat Struct Mol Biol, 2023 Dec. PMID 37696957
    5. Cryo-EM structure of the mitochondrial protein-import channel TOM complex at near-atomic resolution. Tucker K, et al. Nat Struct Mol Biol, 2019 Dec. PMID 31740857, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tom7 recruits Mdm10, enhancing its association with the MMM1 complex, to regulate timing of the release of Tom40 from the TOB complex for subsequent assembly into the TOM40 complex
      Title: Tom7 regulates Mdm10-mediated assembly of the mitochondrial import channel protein Tom40.
    2. The authors report here that the third small Tom protein, Tom7, plays an inhibitory role at two distinct steps in the biogenesis of the translocase of the outer mitochondrial membrane (TOM) complex.
      Title: Biogenesis of mitochondria: dual role of Tom7 in modulating assembly of the preprotein translocase of the outer membrane.
    3. Tom7-mediated segregation of Mdm10 functions by a differentiation of beta-barrel assembly
      Title: Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to protein transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into mitochondrial matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial outer membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane HDA PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial outer membrane translocase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial outer membrane translocase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial outer membrane translocase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tom7p
    NP_014329.1
    • Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      493366..493548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182908.1 → NP_014329.1  TPA: Tom7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014329.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1A9, P53507
      UniProtKB/TrEMBL
      A6ZS10, B3LNS9, C7GIL6, C8ZGG0, G2WM34, N1NZH5
      Conserved Domains (1) summary
      pfam08038
      Location:14 → 54
      Tom7; TOM7 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53507.2

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