TRS20 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TRS20
Primary source: FungiDB:YBR254C
Locus tag: YBR254C
See related: SGD:S000000458; AllianceGenome:SGD:S000000458; VEuPathDB:YBR254C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in cellular protein-containing complex assembly and endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPPI protein complex; TRAPPII protein complex; and TRAPPIII protein complex. Used to study X-linked spondyloepiphyseal dysplasia tarda and spondyloepiphyseal dysplasia congenita. Human ortholog(s) of this gene implicated in X-linked spondyloepiphyseal dysplasia tarda. Orthologous to human TRAPPC2 (trafficking protein particle complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Trs20 plays a role as an adaptor in the assembly of TRAPP II and TRAPP III complexes and is required for autophagy.
Title: Trs20 is required for TRAPP III complex assembly at the PAS and its function in autophagy.
Mutation in Trs20 led to defects in endocytic recycling and a block in sporulation/meiosis.
Title: Mutational analysis of the yeast TRAPP subunit Trs20p identifies roles in endocytic recycling and sporulation.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
part_of TRAPP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TRAPPI protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of TRAPPII protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of TRAPPIII protein complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular organelle	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site	IEA Inferred from Electronic Annotation more info

NP_009813.1

Core component of transport protein particle (TRAPP) complexes I-III; TRAPPs are multimeric guanine nucleotide-exchange factors for GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); mutation leads to defects in endocytic recycling, block in sporulation/meiosis; mutations in human homolog TRAPPC2 cause spondyloepiphyseal dysplasia tarda, TRAPPC2 can complement yeast null mutant

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The following sections contain reference sequences that belong to a specific genome build. Explain