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    TRS23 TRAPP subunit TRS23 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851833, updated on 28-Oct-2024

    Summary

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    Official Symbol
    TRS23
    Official Full Name
    TRAPP subunit TRS23
    Primary source
    SGD:S000002654
    Locus tag
    YDR246W
    See related
    AllianceGenome:SGD:S000002654; FungiDB:YDR246W; VEuPathDB:YDR246W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to guanyl-nucleotide exchange factor activity. Involved in chromosome organization and endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPPI protein complex; TRAPPII protein complex; and TRAPPIII protein complex. Used to study syndromic intellectual disability. Orthologous to human TRAPPC4 (trafficking protein particle complex subunit 4). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See TRS23 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (954288..954947)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pex5p Neighboring gene alpha-1,6-mannosyltransferase Neighboring gene uncharacterized protein Neighboring gene putative serine/threonine protein kinase VHS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deficiencies in vesicular transport mediated by TRAPPC4 are associated with severe syndromic intellectual disability. Van Bergen NJ, et al. Brain, 2020 Jan 1. PMID 31794024, Free PMC Article
    2. TRAPPI tethers COPII vesicles by binding the coat subunit Sec23. Cai H, et al. Nature, 2007 Feb 22. PMID 17287728
    3. The SMS domain of Trs23p is responsible for the in vitro appearance of the TRAPP I complex in Saccharomyces cerevisiae. Brunet S, et al. Cell Logist, 2012 Jan 1. PMID 22645708, Free PMC Article
    4. Trs20 is required for TRAPP III complex assembly at the PAS and its function in autophagy. Taussig D, et al. Traffic, 2014 Mar. PMID 24329977, Free PMC Article
    5. The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes. Cai Y, et al. Cell, 2008 Jun 27. PMID 18585354, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TRAPP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TRAPPI protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPPII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPPIII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagophore assembly site IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TRAPP subunit TRS23
    NP_010532.3
    • Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); human homolog is TRAPPC4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      954288..954947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180554.3 → NP_010532.3  TPA: TRAPP subunit TRS23 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010532.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSM6, Q03784
      UniProtKB/TrEMBL
      A6ZYJ8, B3LG43, B5VGD2, C7GTI1, C8Z5F7, G2WAY9, N1P8H1
      Conserved Domains (1) summary
      COG5122
      Location:1 → 218
      TRS23; Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03784.1

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