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    VID24 glucose-induced degradation complex subunit VID24 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852402, updated on 28-Oct-2024

    Summary

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    Official Symbol
    VID24
    Official Full Name
    glucose-induced degradation complex subunit VID24
    Primary source
    SGD:S000000309
    Locus tag
    YBR105C
    See related
    AllianceGenome:SGD:S000000309; FungiDB:YBR105C; VEuPathDB:YBR105C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GID4
    Summary
    Involved in several processes, including negative regulation of gluconeogenesis; protein catabolic process in the vacuole; and protein targeting to vacuole. Located in cytoplasmic vesicle. Part of GID complex. Orthologous to human GID4 (GID complex subunit 4 homolog). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See VID24 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (450881..451969, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Sif2p Neighboring gene organic acid transporter Neighboring gene Snd3p Neighboring gene Iml3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enhancement of malate-production and increase in sensitivity to dimethyl succinate by mutation of the VID24 gene in Saccharomyces cerevisiae. Negoro H, et al. J Biosci Bioeng, 2016 Jun. PMID 26983942
    2. Recognition of nonproline N-terminal residues by the Pro/N-degron pathway. Dong C, et al. Proc Natl Acad Sci U S A, 2020 Jun 23. PMID 32513738, Free PMC Article
    3. Vid30 is required for the association of Vid vesicles and actin patches in the vacuole import and degradation pathway. Alibhoy AA, et al. Autophagy, 2012 Jan. PMID 22082961, Free PMC Article
    4. Mutation in gene coding for glucose-induced degradation-deficient protein contributes to high malate production in yeast strain No. 28 and No. 77 used for industrial brewing of sake. Negoro H, et al. Biosci Biotechnol Biochem, 2021 Apr 24. PMID 33686405
    5. Vid24p, a novel protein localized to the fructose-1, 6-bisphosphatase-containing vesicles, regulates targeting of fructose-1,6-bisphosphatase from the vesicles to the vacuole for degradation. Chiang MC, et al. J Cell Biol, 1998 Mar 23. PMID 9508768, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutation in gene coding for glucose-induced degradation-deficient protein contributes to high malate production in yeast strain No. 28 and No. 77 used for industrial brewing of sake.
      Title: Mutation in gene coding for glucose-induced degradation-deficient protein contributes to high malate production in yeast strain No. 28 and No. 77 used for industrial brewing of sake.
    2. Data show that Gid4/VID24 is tightly regulated on the transcriptional and protein level to ensure proper adjustment of gluconeogenesis.
      Title: Regulation of the Gid ubiquitin ligase recognition subunit Gid4.
    3. Gid4 subunit of the ubiquitin ligase GID in the yeast Saccharomyces cerevisiae targeted the gluconeogenic enzymes Fbp1, Icl1, and Mdh2 for degradation. Gid4 recognized the N-terminal proline residue and the ~5-residue-long adjacent sequence motifs.
      Title: An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes.
    4. Vid24p and Sec28p are present at actin patches during glucose starvation.
      Title: The vacuole import and degradation pathway utilizes early steps of endocytosis and actin polymerization to deliver cargo proteins to the vacuole for degradation.
    5. the yeast GID complex is a novel ubiquitin ligase (E3) involved in the regulation of carbohydrate metabolism, which is regulated by Gid4/Vid24
      Title: The yeast GID complex, a novel ubiquitin ligase (E3) involved in the regulation of carbohydrate metabolism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein catabolic process in the vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein catabolic process in the vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucose-induced degradation complex subunit VID24
    NP_009663.1
    • GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      450881..451969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178453.1 → NP_009663.1  TPA: glucose-induced degradation complex subunit VID24 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009663.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQA4, P38263
      UniProtKB/TrEMBL
      C7GUK3, D3UEJ8, G2W9B0, N1P9G1
      Conserved Domains (1) summary
      COG5073
      Location:42 → 358
      VID24; Vacuolar import and degradation protein [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38263.1

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