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    WHI2 Whi2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854208, updated on 28-Oct-2024

    Summary

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    Official Symbol
    WHI2
    Official Full Name
    Whi2p
    Primary source
    SGD:S000005569
    Locus tag
    YOR043W
    See related
    AllianceGenome:SGD:S000005569; FungiDB:YOR043W; VEuPathDB:YOR043W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein phosphatase binding activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and positive regulation of G1 to G0 transition. Located in cell periphery. Used to study progressive myoclonus epilepsy 3. Orthologous to human GPATCH1 (G-patch domain containing 1). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See WHI2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (410870..412330)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ubiquitin-binding protein CUE5 Neighboring gene ncRNA Neighboring gene Irc23p Neighboring gene Tom6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The relationship of growth rate and catabolite repression with WHI2 expression and cell size in Saccharomyces cerevisiae. Mountain HA, et al. J Gen Microbiol, 1990 Apr. PMID 2204680
    2. Transcript characterisation, gene disruption and nucleotide sequence of the Saccharomyces cerevisiae WH12 gene. Kelly DE, et al. Gene, 1988 Jun 30. PMID 3049245
    3. Molecular cloning of WHI2, a gene involved in the regulation of cell proliferation in Saccharomyces cerevisiae. Saul DJ, et al. J Gen Microbiol, 1985 Jul. PMID 3900284
    4. Effects of abolishing Whi2 on the proteome and nitrogen catabolite repression-sensitive protein production. Tate JJ, et al. G3 (Bethesda), 2022 Mar 4. PMID 35100365, Free PMC Article
    5. YPK9 and WHI2 Negatively Interact during Oxidative Stress. Joseph F, et al. Microorganisms, 2021 Dec 14. PMID 34946185, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effects of abolishing Whi2 on the proteome and nitrogen catabolite repression-sensitive protein production.
      Title: Effects of abolishing Whi2 on the proteome and nitrogen catabolite repression-sensitive protein production.
    2. Whi2 inhibits TORC1 activity through its binding partners, protein phosphatases Psr1 and Psr2, which were previously thought to only regulate amino acid levels downstream of TORC1.
      Title: Whi2 is a conserved negative regulator of TORC1 in response to low amino acids.
    3. Overexpression of WHI2 significantly improved glucose and/or xylose fermentation under acetic acid stress.
      Title: Improved Acetic Acid Resistance in Saccharomyces cerevisiae by Overexpression of the WHI2 Gene Identified through Inverse Metabolic Engineering.
    4. The diminished mitophagy initially observed in a Deltafis1 mutant was due to a secondary mutation in WHI2.
      Title: Mitophagy in yeast is independent of mitochondrial fission and requires the stress response gene WHI2.
    5. Data demonstrate that Whi2p-dependent regulation of cAMP-PKA signalling plays a physiological role in the differentiation of yeast colonies by facilitating elaboration of distinct zones of cell death.
      Title: Whi2p links nutritional sensing to actin-dependent Ras-cAMP-PKA regulation and apoptosis in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to amino acid starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to amino acid starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of G1 to G0 transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Whi2p
    NP_014686.1
    • Negative regulator of TORC1 in response to limiting leucine; suppresses TORC1 activity with binding partners Psr1p/Psr2p, acting in parallel with SEACIT; regulates cell cycle arrest in stationary phase; inhibits Ras-cAMP-PKA regulation of apoptosis during nutrient depletion; required with Psr1p for activation of the general stress response; role in rapamycin-induced mitophagy; localizes to the cell periphery; human tumor suppressor and Whi2-like protein KCTD11 functionally complements the null

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      410870..412330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183462.1 → NP_014686.1  TPA: Whi2p [Saccharomyces cerevisiae S288C]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2A9, P12611, Q08413
      UniProtKB/TrEMBL
      C8ZI05, G2WMS4, N1NWV1
      Conserved Domains (1) summary
      cl38908
      Location:42 → 112
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12611.2

    Gene LinkOut

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