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    BUD14 protein phosphatase regulator BUD14 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851271, updated on 1-Aug-2024

    Summary

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    Gene symbol
    BUD14
    Gene description
    protein phosphatase regulator BUD14
    Primary source
    FungiDB:YAR014C
    Locus tag
    YAR014C
    See related
    SGD:S000000069; AllianceGenome:SGD:S000000069; VEuPathDB:YAR014C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein phosphatase regulator activity. Involved in several processes, including regulation of actin filament organization; regulation of cell shape; and regulation of cytokinesis. Located in cellular bud neck and cellular bud tip. Part of Kelch-containing formin regulatory complex and incipient cellular bud site. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See BUD14 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (166742..168871, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene tRNA-Ala Neighboring gene phosphoribosylaminoimidazolesuccinocarboxamide synthase Neighboring gene serine/threonine protein kinase KIN3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential genetic interactions of yeast stress response MAPK pathways. Martin H, et al. Mol Syst Biol, 2015 Apr 17. PMID 25888283, Free PMC Article
    2. The Glc7p-interacting protein Bud14p attenuates polarized growth, pheromone response, and filamentous growth in Saccharomyces cerevisiae. Cullen PJ, et al. Eukaryot Cell, 2002 Dec. PMID 12477789, Free PMC Article
    3. Common formin-regulating sequences in Smy1 and Bud14 are required for the control of actin cable assembly in vivo. Eskin JA, et al. Mol Biol Cell, 2016 Mar 1. PMID 26764093, Free PMC Article
    4. The myosin passenger protein Smy1 controls actin cable structure and dynamics by acting as a formin damper. Chesarone-Cataldo M, et al. Dev Cell, 2011 Aug 16. PMID 21839918, Free PMC Article
    5. Saccharomyces cerevisiae Kelch proteins and Bud14 protein form a stable 520-kDa formin regulatory complex that controls actin cable assembly and cell morphogenesis. Gould CJ, et al. J Biol Chem, 2014 Jun 27. PMID 24828508, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein phosphatase 1 in association with Bud14 inhibits mitotic exit in Saccharomyces cerevisiae.
      Title: Protein phosphatase 1 in association with Bud14 inhibits mitotic exit in Saccharomyces cerevisiae.
    2. Formin-regulating sequences in Smy1 and Bud14 are required for the control of actin cable assembly.
      Title: Common formin-regulating sequences in Smy1 and Bud14 are required for the control of actin cable assembly in vivo.
    3. Bud14, Kel1, and Kel2 interact to form a stable 520-kDa complex that controls actin cable assembly and cell morphogenesis.
      Title: Saccharomyces cerevisiae Kelch proteins and Bud14 protein form a stable 520-kDa formin regulatory complex that controls actin cable assembly and cell morphogenesis.
    4. formin displacement from growing barbed ends by bud14 is critical for actin cable architecture and function
      Title: Displacement of formins from growing barbed ends by bud14 is critical for actin cable architecture and function.
    5. the Ccr4-Not complex independently controls TFIID promoter distribution and Msn2-dependent trans-activation through a process involving a Glc7/Bud14 phosphatase
      Title: The Ccr4-Not complex independently controls both Msn2-dependent transcriptional activation--via a newly identified Glc7/Bud14 type I protein phosphatase module--and TFIID promoter distribution.
    6. Bud14p functions as a regulatory subunit of the Glc7p type-I phosphatase to stabilize MT interactions specifically at sites of polarized growth.
      Title: The Bud14p-Glc7p complex functions as a cortical regulator of dynein in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of actin cytoskeleton polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of actin filament polymerization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of formin-nucleated actin cable assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Kelch-containing formin regulatory complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    protein phosphatase regulator BUD14
    NP_009408.3
    • Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; forms a complex with Kel1p and Kel2p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      166742..168871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178215.2 → NP_009408.3  TPA: protein phosphatase regulator BUD14 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009408.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPM3, P27637
      UniProtKB/TrEMBL
      A7A0H2, C7GUF5, N1P8X7
      Conserved Domains (1) summary
      pfam00018
      Location:266 → 312
      SH3_1; SH3 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27637.4

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