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    gag-pol fusion protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850340, updated on 2-Nov-2024

    Summary

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    Official Full Name
    gag-pol fusion protein
    Primary source
    SGD:S000000524
    Locus tag
    YCL019W
    See related
    AllianceGenome:SGD:S000000524; FungiDB:YCL019W; VEuPathDB:YCL019W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable several functions, including DNA polymerase activity; RNA nuclease activity; and peptidase activity. Predicted to be involved in retrotransposition. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (85102..90415)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene tRNA-Glu Neighboring gene uncharacterized protein Neighboring gene gag protein Neighboring gene tRNA-Leu Neighboring gene 3-isopropylmalate dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Invading the yeast nucleus: a nuclear localization signal at the C terminus of Ty1 integrase is required for transposition in vivo. Kenna MA, et al. Mol Cell Biol, 1998 Feb. PMID 9448009, Free PMC Article
    2. Ty1 gag enhances the stability and nuclear export of Ty1 mRNA. Checkley MA, et al. Traffic, 2013 Jan. PMID 22998189, Free PMC Article
    3. Happy together: the life and times of Ty retrotransposons and their hosts. Lesage P, et al. Cytogenet Genome Res, 2005. PMID 16093660
    4. Evolutionary genomics of transposable elements in Saccharomyces cerevisiae. Carr M, et al. PLoS One, 2012. PMID 23226439, Free PMC Article
    5. Transposable elements and genome organization: a comprehensive survey of retrotransposons revealed by the complete Saccharomyces cerevisiae genome sequence. Kim JM, et al. Genome Res, 1998 May. PMID 9582191

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA nuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA-DNA hybrid ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-directed DNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA integration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA-templated DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrotransposition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in transposition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in viral translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in retrotransposon nucleocapsid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gag-pol fusion protein
    NP_009909.2
    • Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      85102..90415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178666.2 → NP_009909.2  TPA: gag-pol fusion protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009909.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQZ4, P25384, P87006
      UniProtKB/TrEMBL
      C8Z493
      Conserved Domains (5) summary
      cd09272
      Location:1621 → 1757
      RNase_HI_RT_Ty1; Ty1/Copia family of RNase HI in long-term repeat retroelements
      pfam00665
      Location:660 → 778
      rve; Integrase core domain
      pfam01021
      Location:17 → 114
      TYA; TYA transposon protein
      pfam07727
      Location:1296 → 1489
      RVT_2; Reverse transcriptase (RNA-dependent DNA polymerase)
      pfam13976
      Location:574 → 641
      gag_pre-integrs; GAG-pre-integrase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25384.2

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