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    LSB5 Lsb5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850323, updated on 3-Nov-2024

    Summary

    Official Symbol
    LSB5
    Official Full Name
    Lsb5p
    Primary source
    SGD:S000000539
    Locus tag
    YCL034W
    See related
    AllianceGenome:SGD:S000000539; FungiDB:YCL034W; VEuPathDB:YCL034W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in actin cortical patch localization; actin filament organization; and endocytosis. Located in actin cortical patch. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See LSB5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (61658..62722)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Gfd2p Neighboring gene dithiol glutaredoxin GRX1 Neighboring gene peptide-methionine (R)-S-oxide reductase Neighboring gene Ste50p

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in actin cortical patch localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin cortical patch localization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin filament organization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocytosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in actin cortical patch IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol HDA PubMed 

    General protein information

    Preferred Names
    Lsb5p
    NP_009896.2
    • Protein involved in membrane-trafficking events at plasma membrane; interacts with actin regulators Sla1p and Las17p, ubiquitin, Arf3p to couple actin dynamics to membrane trafficking processes; similar structure to GGA family of proteins with N-terminal VHS domain and GAT domain; binds Las17p, which is homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly, actin polymerization; may mediate disassembly of Pan1 complex from endocytic coat

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      61658..62722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178679.1NP_009896.2  TPA: Lsb5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009896.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQY1, P25369, P87004, Q8NIM9
      UniProtKB/TrEMBL
      A6ZTF6, B3LU48, B5VES5, C7GSZ1, C8Z455, G2W9Z1, N1P986
      Conserved Domains (2) summary
      cd16980
      Location:12158
      VHS_Lsb5; VHS (Vps27/Hrs/STAM) domain of LAS seventeen-binding protein 5
      cd14232
      Location:219295
      GAT_LSB5; canonical GAT domain found in yeast LAS seventeen-binding protein 5 (Lsb5p) and similar proteins