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    SCM3 Scm3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851416, updated on 2-Nov-2024

    Summary

    Official Symbol
    SCM3
    Official Full Name
    Scm3p
    Primary source
    SGD:S000002298
    Locus tag
    YDL139C
    See related
    AllianceGenome:SGD:S000002298; FungiDB:YDL139C; VEuPathDB:YDL139C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables CENP-A containing nucleosome binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; kinetochore assembly; and negative regulation of ubiquitin-dependent protein catabolic process. Located in condensed chromosome, centromeric region. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See SCM3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (211375..212046, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene biotin--[acetyl-CoA-carboxylase] ligase BPL1 Neighboring gene DNA-directed RNA polymerase II core subunit RPO21 Neighboring gene glucose sensor Neighboring gene Arf family GTPase ARF2

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    Scm3p
    NP_010142.2
    • Non-histone component of centromeric chromatin; acts as a Cse4p specific chaperone that recognizes the centromere-targeting domain in the HFD of histone H3 variant, Cse4p, and recruits it to centromeres; involved in the assembly and maintenance of Cse4-H4 at centromeres; required for kinetochore assembly and G2/M progression; may protect Cse4p from ubiquitination; homolog of mammalian HJURP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      211375..212046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180199.1NP_010142.2  TPA: Scm3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010142.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRK9, Q12334
      UniProtKB/TrEMBL
      C7GKZ1, G2WC22, N1P7V3
      Conserved Domains (1) summary
      pfam10384
      Location:92141
      Scm3; Centromere protein Scm3