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    RAV2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851784, updated on 22-Aug-2024

    Summary

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    Official Symbol
    RAV2
    Primary source
    FungiDB:YDR202C
    Locus tag
    YDR202C
    See related
    SGD:S000002610; AllianceGenome:SGD:S000002610; VEuPathDB:YDR202C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in regulation of protein-containing complex assembly and vacuolar acidification. Part of RAVE complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (856898..857953, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Vps64p Neighboring gene Spc19p Neighboring gene ubiquinone biosynthesis protein COQ4 Neighboring gene metal cation transporter MSC2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the complex involved in regulating V-ATPase activity of the vacuolar and endosomal membrane. Zhang Z, et al. J Bioenerg Biomembr, 2017 Oct. PMID 28643238
    2. Molecular Interactions and Cellular Itinerary of the Yeast RAVE (Regulator of the H+-ATPase of Vacuolar and Endosomal Membranes) Complex. Smardon AM, et al. J Biol Chem, 2015 Nov 13. PMID 26405040, Free PMC Article
    3. RAVE is essential for the efficient assembly of the C subunit with the vacuolar H(+)-ATPase. Smardon AM, et al. J Biol Chem, 2007 Sep 7. PMID 17623654
    4. Interaction between the yeast RAVE complex and Vph1-containing V(o) sectors is a central glucose-sensitive interaction required for V-ATPase reassembly. Jaskolka MC, et al. J Biol Chem, 2020 Feb 21. PMID 31941791, Free PMC Article
    5. Defining steps in RAVE-catalyzed V-ATPase assembly using purified RAVE and V-ATPase subcomplexes. Jaskolka MC, et al. J Biol Chem, 2021 Jan-Jun. PMID 33895134, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein-containing complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein-containing complex assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in vacuolar acidification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vacuolar acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RAVE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RAVE complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rav2p
    NP_010488.1
    • Subunit of RAVE complex (Rav1p, Rav2p, Skp1p); the RAVE complex associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      856898..857953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180510.1 → NP_010488.1  TPA: Rav2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010488.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSI4, Q03956
      UniProtKB/TrEMBL
      A6ZYG0, B3LG82, B5VG94, C7GMZ6, C8Z5B7, G2WAV0, N1P4Y3
      Conserved Domains (1) summary
      pfam10259
      Location:26 → 341
      Rogdi_lz; Rogdi leucine zipper containing protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03956.1

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