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    CRF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851809, updated on 22-Aug-2024

    Summary

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    Official Symbol
    CRF1
    Primary source
    FungiDB:YDR223W
    Locus tag
    YDR223W
    See related
    SGD:S000002631; AllianceGenome:SGD:S000002631; VEuPathDB:YDR223W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables transcription corepressor activity. Involved in negative regulation of ribosomal protein gene transcription by RNA polymerase II. Located in chromatin; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (912099..913502)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Gtb1p Neighboring gene uncharacterized protein Neighboring gene histone H2B Neighboring gene histone H2A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene duplication and the evolution of ribosomal protein gene regulation in yeast. Wapinski I, et al. Proc Natl Acad Sci U S A, 2010 Mar 23. PMID 20212107, Free PMC Article
    2. Fine-structure analysis of ribosomal protein gene transcription. Zhao Y, et al. Mol Cell Biol, 2006 Jul. PMID 16782874, Free PMC Article
    3. DNA damage regulates direct association of TOR kinase with the RNA polymerase II-transcribed HMO1 gene. Panday A, et al. Mol Biol Cell, 2017 Sep 1. PMID 28701348, Free PMC Article
    4. Determination of the core promoter regions of the Saccharomyces cerevisiae RPS3 gene. Joo YJ, et al. Biochim Biophys Acta, 2009 Nov-Dec. PMID 19853675
    5. Mutational analysis of the Lem3p-Dnf1p putative phospholipid-translocating P-type ATPase reveals novel regulatory roles for Lem3p and a carboxyl-terminal region of Dnf1p independent of the phospholipid-translocating activity of Dnf1p in yeast. Noji T, et al. Biochem Biophys Res Commun, 2006 May 26. PMID 16600184

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yeast Crf1p is an activator with different roles in regulation of target genes.
      Title: Yeast Crf1p is an activator with different roles in regulation of target genes.
    2. The role of CK2-dependent phosphorylation of Ifh1 and Crf1 in transcriptional regulation of ribosomal protein genes in Saccharomyces cerevisiae has been described.
      Title: Role of CK2-dependent phosphorylation of Ifh1 and Crf1 in transcriptional regulation of ribosomal protein genes in Saccharomyces cerevisiae.
    3. Studies confirmed the promoter occupancy of RPS3 by Rap1p and other transcription factors Sfp1p, Hmo1p and Crf1p.
      Title: Determination of the core promoter regions of the Saccharomyces cerevisiae RPS3 gene.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of ribosomal protein gene transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ribosomal protein gene transcription by RNA polymerase II IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of ribosomal protein gene transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Crf1p
    NP_010509.1
    • Transcriptional corepressor; involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain; CRF1 has a paralog, IFH1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      912099..913502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180531.1 → NP_010509.1  TPA: Crf1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010509.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSK5, Q04930
      UniProtKB/TrEMBL
      B3LG64, G2WAW8, N1P6L7
      Conserved Domains (1) summary
      pfam10380
      Location:345 → 409
      CRF1; Transcription factor CRF1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04930.1

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