CIA1 iron-sulfur cluster assembly protein CIA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CIA1
Official Full Name: iron-sulfur cluster assembly protein CIA1
Primary source: SGD:S000002675
Locus tag: YDR267C
See related: AllianceGenome:SGD:S000002675; FungiDB:YDR267C; VEuPathDB:YDR267C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in protein maturation by iron-sulfur cluster transfer and tRNA wobble uridine modification. Located in cytosol and nucleus. Part of cytosolic [4Fe-4S] assembly targeting complex. Orthologous to human CIAO1 (cytosolic iron-sulfur assembly component 1). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See CIA1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1002510..1003502, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data provide the framework for a postreplicative recombination mechanism controlled by histone modifiers Rtt109 and histone chaperones Cia1/Asf1 in multiple ways.
Title: Chromatin dynamics mediated by histone modifiers and histone chaperones in postreplicative recombination.
The crystal structure of the evolutionarily conserved domain (residues 1-169) of Cia1p (ScCia1p-DeltaC2) was determined at 2.95 A resolution
Title: Structural similarity between histone chaperone Cia1p/Asf1p and DNA-binding protein NF-kappaB.
the crystal structure of Saccharomyces cerevisiae Cia1 to 1.7 A resolution.
Title: Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis.
Cia1 is a new member of the cytosolic Fe/S protein assembly (CIA) machinery participating in a step after Nbp35 and Nar1.
Title: The essential WD40 protein Cia1 is involved in a late step of cytosolic and nuclear iron-sulfur protein assembly.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in iron-sulfur cluster assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info
involved_in protein maturation by iron-sulfur cluster transfer	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein maturation by iron-sulfur cluster transfer	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA wobble uridine modification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic [4Fe-4S] assembly targeting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic [4Fe-4S] assembly targeting complex	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic [4Fe-4S] assembly targeting complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: iron-sulfur cluster assembly protein CIA1

NP_010553.3

Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at late step of Fe-S cluster assembly; forms CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation and maturation of a subset of cytosolic and nuclear proteins involved in methionine biosynthesis, DNA replication and repair, transcription and telomere maintenance; contains WD40 repeats; human homolog CIAO1 complements the yeast cia1 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1002510..1003502 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180575.3 → NP_010553.3 TPA: iron-sulfur cluster assembly protein CIA1 [Saccharomyces cerevisiae S288C]

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZYM0, D6VSQ1, Q05583

UniProtKB/TrEMBL

B3LG23, B5VGF1, C7GS88, C8Z5I0, G2WB10, N1P543

Conserved Domains (2) summary

cd00200
Location:6 → 325

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:63 → 105

7WD40; WD40 repeat [structural motif]