YER138C gag-pol fusion protein [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: YER138C
Gene description: gag-pol fusion protein
Primary source: FungiDB:YER138C
Locus tag: YER138C
See related: SGD:S000000940; AllianceGenome:SGD:S000000940; VEuPathDB:YER138C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable several functions, including DNA polymerase activity; peptidase activity; and ribonuclease activity. Predicted to be involved in transposition, RNA-mediated. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YER138C in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (443756..449024, complement)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables DNA-directed DNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA nuclease activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA-DNA hybrid ribonuclease activity	IEA Inferred from Electronic Annotation more info
enables RNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables RNA-directed DNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in DNA integration	IEA Inferred from Electronic Annotation more info
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in RNA-templated DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in retrotransposition	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in transposition	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in retrotransposon nucleocapsid	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: gag-pol fusion protein

NP_011064.3

EC 2.7.7.49

EC 2.7.7.7

EC 3.1.26.4

Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

443756..449024 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179028.4 → NP_011064.3 TPA: gag-pol fusion protein [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011064.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DM43, Q03612, Q07163, Q07169

Conserved Domains (4) summary

cd09272
Location:1606 → 1742

RNase_HI_RT_Ty1; Ty1/Copia family of RNase HI in long-term repeat retroelements

pfam00665
Location:663 → 765

rve; Integrase core domain

pfam01021
Location:17 → 114

TYA; TYA transposon protein

pfam07727
Location:1280 → 1498

RVT_2; Reverse transcriptase (RNA-dependent DNA polymerase)