U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    YFH1 ferroxidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851437, updated on 17-May-2024

    Summary

    Gene symbol
    YFH1
    Gene description
    ferroxidase
    Primary source
    FungiDB:YDL120W
    Locus tag
    YDL120W
    See related
    SGD:S000002278; AllianceGenome:SGD:S000002278; VEuPathDB:YDL120W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ferrous iron binding activity; ferroxidase activity; and iron chaperone activity. Involved in cellular iron ion homeostasis; glutathione metabolic process; and iron-sulfur cluster assembly. Located in mitochondrial matrix. Used to study Friedreich ataxia; cancer; and iron metabolism disease. Human ortholog(s) of this gene implicated in Friedreich ataxia; Friedreich ataxia 1; and type 2 diabetes mellitus. Orthologous to human FXN (frataxin). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See YFH1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (245923..246447)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ubiquitin-specific protease UBP1 Neighboring gene Exp1p Neighboring gene Hem25p Neighboring gene Cyk3p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ferric iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ferric iron binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ferroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ferroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ferroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron chaperone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables iron chaperone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables iron chaperone activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular iron ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular iron ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in iron incorporation into metallo-sulfur cluster IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in iron-sulfur cluster assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in iron-sulfur cluster assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in iron-sulfur cluster assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in iron-sulfur cluster assembly IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ferroxidase
    NP_010163.1
    • Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog FXN is mutated in Friedrich's ataxia; human FTL gene can complement yeast yfh1 null mutant

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      245923..246447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180179.1NP_010163.1  TPA: ferroxidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010163.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRN0, Q07540
      UniProtKB/TrEMBL
      A0A6A5PZ28, A6ZXL0, B3LH10, B5VFE8, C7GJJ6, C8Z6I3, G2WC42, N1P7K6
      Conserved Domains (1) summary
      TIGR03422
      Location:72168
      mito_frataxin; frataxin