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    IOC3 Ioc3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850567, updated on 28-Oct-2024

    Summary

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    Official Symbol
    IOC3
    Official Full Name
    Ioc3p
    Primary source
    SGD:S000001909
    Locus tag
    YFR013W
    See related
    AllianceGenome:SGD:S000001909; FungiDB:YFR013W; VEuPathDB:YFR013W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to ATP hydrolysis activity; DNA binding activity; and nucleosome binding activity. Involved in sister chromatid cohesion. Part of Isw1a complex. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See IOC3 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (169922..172285)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Dcv1p Neighboring gene uncharacterized protein Neighboring gene calmodulin-dependent protein kinase CMK1 Neighboring gene glycogen (starch) synthase GSY1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the ISW1a complex bound to the dinucleosome. Li L, et al. Nat Struct Mol Biol, 2024 Feb. PMID 38177688
    2. Dynamic regulation of transcription factors by nucleosome remodeling. Li M, et al. Elife, 2015 Jun 5. PMID 26047462, Free PMC Article
    3. ATP-independent cooperative binding of yeast Isw1a to bare and nucleosomal DNA. De Cian A, et al. PLoS One, 2012. PMID 22359636, Free PMC Article
    4. Structure and mechanism of the chromatin remodelling factor ISW1a. Yamada K, et al. Nature, 2011 Apr 28. PMID 21525927
    5. Isw1 acts independently of the Isw1a and Isw1b complexes in regulating transcriptional silencing at the ribosomal DNA locus in Saccharomyces cerevisiae. Mueller JE, et al. J Mol Biol, 2007 Aug 3. PMID 17561109, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to nucleosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Isw1a complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ioc3p
    NP_116668.1
    • Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; promotes nucleosome shifts in the 5 prime direction; IOC3 has a paralog, ESC8, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      169922..172285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179978.1 → NP_116668.1  TPA: Ioc3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116668.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTP4, P43596
      UniProtKB/TrEMBL
      G2WDF2
      Conserved Domains (1) summary
      pfam15612
      Location:365 → 411
      WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43596.1

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