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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850573, updated on 28-Oct-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000001914
    Locus tag
    YFR018C
    See related
    AllianceGenome:SGD:S000001914; FungiDB:YFR018C; VEuPathDB:YFR018C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Located in endoplasmic reticulum. Orthologous to human QPCT (glutaminyl-peptide cyclotransferase) and QPCTL (glutaminyl-peptide cyclotransferase like). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (183131..184222, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene Igd1p Neighboring gene 1-phosphatidylinositol-3-phosphate 5-kinase Neighboring gene tRNA-Ser

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identifying Interaction Partners of Yeast Protein Disulfide Isomerases Using a Small Thiol-Reactive Cross-Linker: Implications for Secretory Pathway Proteostasis. Freije BJ, et al. Chem Res Toxicol, 2022 Feb 21. PMID 35084835, Free PMC Article
    2. Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae. Murakami Y, et al. Nat Genet, 1995 Jul. PMID 7670463
    3. Global analysis of SUMO chain function reveals multiple roles in chromatin regulation. Srikumar T, et al. J Cell Biol, 2013 Apr 1. PMID 23547032, Free PMC Article
    4. J domain co-chaperone specificity defines the role of BiP during protein translocation. Vembar SS, et al. J Biol Chem, 2010 Jul 16. PMID 20430885, Free PMC Article
    5. The cellular economy of the Saccharomyces cerevisiae zinc proteome. Wang Y, et al. Metallomics, 2018 Dec 12. PMID 30358795, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutaminyl-peptide cyclotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutaminyl-peptide cyclotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_116673.1
    • hypothetical protein; SWAT-GFP and seamless GFP fusion proteins localize to the endoplasmic reticulum and mCherry fusion protein localizes to the vacuole

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      183131..184222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179983.1 → NP_116673.1  TPA: uncharacterized protein YFR018C [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116673.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTP9, P43599
      UniProtKB/TrEMBL
      B3LUM7, C7GYC4
      Conserved Domains (1) summary
      cd03880
      Location:36 → 356
      M28_QC_like; M28 Zn-peptidase glutaminyl cyclase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43599.1

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