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    RIM8 Rim8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852837, updated on 17-May-2024

    Summary

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    Gene symbol
    RIM8
    Gene description
    Rim8p
    Primary source
    FungiDB:YGL045W
    Locus tag
    YGL045W
    See related
    SGD:S000003013; AllianceGenome:SGD:S000003013; VEuPathDB:YGL045W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ART9; PAL3; YGL046W
    Summary
    Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Involved in several processes, including invasive growth in response to glucose limitation; protein processing; and ubiquitin-dependent endocytosis. Located in cytoplasmic side of plasma membrane. Orthologous to human ARRDC1 (arrestin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RIM8 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (414102..415730)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13 Neighboring gene tRNA-Val Neighboring gene Rna15p Neighboring gene transcription elongation factor DST1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ambient pH signalling in ascomycetous yeasts involves homologues of the Aspergillus nidulans genes palF and paIH. Tréton B, et al. Mol Gen Genet, 2000 Apr. PMID 10821185
    2. Evolutionary engineering and molecular characterization of a caffeine-resistant Saccharomyces cerevisiae strain. Sürmeli Y, et al. World J Microbiol Biotechnol, 2019 Nov 14. PMID 31728740
    3. Proteolytic activation of Rim1p, a positive regulator of yeast sporulation and invasive growth. Li W, et al. Genetics, 1997 Jan. PMID 9017390, Free PMC Article
    4. Loss of vacuolar H+-ATPase activity in organelles signals ubiquitination and endocytosis of the yeast plasma membrane proton pump Pma1p. Smardon AM, et al. J Biol Chem, 2014 Nov 14. PMID 25271159, Free PMC Article
    5. Microfluidic genome-wide profiling of intrinsic electrical properties in Saccharomyces cerevisiae. Vahey MD, et al. Lab Chip, 2013 Jul 21. PMID 23661198, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CK1-mediated phosphorylation of Rim8 contributes to setting a signaling threshold required to inhibit the RIM pathway at acidic pH.
      Title: Casein kinase 1 controls the activation threshold of an α-arrestin by multisite phosphorylation of the interdomain hinge.
    2. found that in Saccharomyces cerevisiae, Rim8 binds to both the putative seven-transmembrane pH sensor Rim21 and the endosomal sorting complex required for transport-I subunit Vps23.
      Title: Recruitment of the ESCRT machinery to a putative seven-transmembrane-domain receptor is mediated by an arrestin-related protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rim8p
    NP_011470.4
    • Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      414102..415730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180910.3 → NP_011470.4  TPA: Rim8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011470.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU94, P53179, P53180, Q9URQ4
      UniProtKB/TrEMBL
      A0A8H4FCV5, G2WE50, N1P391
      Conserved Domains (2) summary
      pfam02752
      Location:259 → 392
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:39 → 201
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53179.2

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