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    ROG1 putative lipase ROG1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852733, updated on 17-May-2024

    Summary

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    Gene symbol
    ROG1
    Gene description
    putative lipase ROG1
    Primary source
    FungiDB:YGL144C
    Locus tag
    YGL144C
    See related
    SGD:S000003112; AllianceGenome:SGD:S000003112; VEuPathDB:YGL144C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables acylglycerol lipase activity. Involved in cellular lipid metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ROG1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (232450..234507, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Rrt6p Neighboring gene Tip20p Neighboring gene Mrf1p Neighboring gene putative glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ROG1 encodes a monoacylglycerol lipase in Saccharomyces cerevisiae. Vishnu Varthini L, et al. FEBS Lett, 2015 Jan 2. PMID 25433290
    2. Disruption of six novel ORFs from Saccharomyces cerevisiae chromosome VII and phenotypic analysis of the deletants. Victoria Escribano M, et al. Yeast, 2000 May. PMID 10806424
    3. Systematic analysis of yeast strains with possible defects in lipid metabolism. Daum G, et al. Yeast, 1999 May. PMID 10341423
    4. The sequence of a nearly unclonable 22.8 kb segment on the left arm chromosome VII from Saccharomyces cerevisiae reveals ARO2, RPL9A, TIP1, MRF1 genes and six new open reading frames. Voet M, et al. Yeast, 1997 Feb. PMID 9046099
    5. Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5. Andoh T, et al. Mol Cell Biol, 2000 Sep. PMID 10958669, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that Rog1p is a MAG lipase that regulates lipid homeostasis.
      Title: ROG1 encodes a monoacylglycerol lipase in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative lipase ROG1
    NP_011371.1
    • Lipase with specificity for monoacylglycerol; preferred substrate is 1-oleoylglycerol; null mutation affects lipid droplet morphology and overexpression causes increased accumulation of reactive oxygen species

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      232450..234507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181009.1 → NP_011371.1  TPA: putative lipase ROG1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011371.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU05, P53118, Q66RA3
      UniProtKB/TrEMBL
      A0A8H4C198, B3LHJ9, C7GPQ9, C8Z8A6, N1P587
      Conserved Domains (1) summary
      pfam05057
      Location:184 → 382
      DUF676; Putative serine esterase (DUF676)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53118.1

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