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    DPC29 Dpc29p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852904, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DPC29
    Official Full Name
    Dpc29p
    Primary source
    SGD:S000003253
    Locus tag
    YGR021W
    See related
    AllianceGenome:SGD:S000003253; FungiDB:YGR021W; VEuPathDB:YGR021W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Acts upstream of or within mitochondrial translation. Located in mitochondrion. Is active in matrix side of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 8. Orthologous to human TACO1 (translational activator of cytochrome c oxidase I). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See DPC29 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (527632..528504)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene 4-aminobutyrate transaminase Neighboring gene H(+)-transporting V1 sector ATPase subunit F Neighboring gene Mtl1p Neighboring gene tRNA-Asp

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DPC29 promotes post-initiation mitochondrial translation in Saccharomyces cerevisiae. Hubble KA, et al. Nucleic Acids Res, 2023 Feb 22. PMID 36620885, Free PMC Article
    2. Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation. Kuhn AN, et al. Genetics, 2000 Aug. PMID 10924465, Free PMC Article
    3. Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale. Morgenstern M, et al. Cell Rep, 2017 Jun 27. PMID 28658629, Free PMC Article
    4. Molecular Connectivity of Mitochondrial Gene Expression and OXPHOS Biogenesis. Singh AP, et al. Mol Cell, 2020 Sep 17. PMID 32877643
    5. Elucidation of the interaction proteome of mitochondrial chaperone Hsp78 highlights its role in protein aggregation during heat stress. Jaworek W, et al. J Biol Chem, 2022 Oct. PMID 36115461, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DPC29 promotes post-initiation mitochondrial translation in Saccharomyces cerevisiae.
      Title: DPC29 promotes post-initiation mitochondrial translation in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mitochondrial translation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in matrix side of mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dpc29p
    NP_011535.1
    • General post-initiation mitochondrial translation factor; peripherally associated with the matrix side of the mitochondrial inner membrane; interacts with mitoribosomal proteins in actively translating cells; human ortholog TACO1 complements the yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      527632..528504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181150.1 → NP_011535.1  TPA: Dpc29p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011535.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUF6, P53212
      UniProtKB/TrEMBL
      A6ZV11, B3LIJ7, B5VIY1, C7GK89, C8Z8R5, G2WEB2, N1P225
      Conserved Domains (1) summary
      COG0217
      Location:26 → 289
      TACO1; Transcriptional and/or translational regulatory protein YebC/TACO1 [Transcription, Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53212.1

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