U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ADE6 phosphoribosylformylglycinamidine synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852952, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ADE6
    Official Full Name
    phosphoribosylformylglycinamidine synthase
    Primary source
    SGD:S000003293
    Locus tag
    YGR061C
    See related
    AllianceGenome:SGD:S000003293; FungiDB:YGR061C; VEuPathDB:YGR061C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphoribosylformylglycinamidine synthase activity. Involved in purine nucleotide biosynthetic process. Located in cytoplasm. Orthologous to human PFAS (phosphoribosylformylglycinamidine synthase). [provided by Alliance of Genome Resources, Oct 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ADE6 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (611889..615965, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene methylsterol monooxygenase Neighboring gene membrane insertase COX18 Neighboring gene transcription elongation factor SPT4

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Recombination in Saccharomyces cerevisiae: a DNA repair mutation associated with elevated mitotic gene conversion. Boram WR, et al. Proc Natl Acad Sci U S A, 1976 Aug. PMID 785473, Free PMC Article
    2. Cloning and transcriptional analysis of the ADE6 gene of Saccharomyces cerevisiae. Gianì S, et al. Gene, 1991 Oct 30. PMID 1743513
    3. Induction of mitotic chromosome loss in the diploid yeast Saccharomyces cerevisiae D61.M by genotoxic carcinogens and tumor promoters. Albertini S, et al. Environ Mol Mutagen, 1988. PMID 3286249
    4. Cyclic AMP may not be involved in catabolite repression in Saccharomyes cerevisiae: evidence from mutants capable of utilizing it as an adenine source. Matsumoto K, et al. J Bacteriol, 1982 Apr. PMID 6277865, Free PMC Article
    5. ADE6 gene of Saccharomyces cerevisiae yeast encoding formylglycinamidine-ribonucleotide synthetase. Cloning, sequencing, and analysis. Andreichuk YuV, et al. Biochemistry (Mosc), 1997 Jul. PMID 9331966

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylformylglycinamidine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylformylglycinamidine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylformylglycinamidine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    phosphoribosylformylglycinamidine synthase
    NP_011575.1
    • Formylglycinamidine-ribonucleotide (FGAM)-synthetase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      611889..615965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181190.1 → NP_011575.1  TPA: phosphoribosylformylglycinamidine synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011575.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUJ6, P38972
      UniProtKB/TrEMBL
      A6ZV46, B3LIG2, B5VJ11, C7GXP4, C8Z8V5, N1P9V4
      Conserved Domains (1) summary
      PRK05297
      Location:5 → 1358
      PRK05297; phosphoribosylformylglycinamidine synthase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38972.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous