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    UTP22 rRNA-processing protein UTP22 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852982, updated on 2-Nov-2024

    Summary

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    Official Symbol
    UTP22
    Official Full Name
    rRNA-processing protein UTP22
    Primary source
    SGD:S000003322
    Locus tag
    YGR090W
    See related
    AllianceGenome:SGD:S000003322; FungiDB:YGR090W; VEuPathDB:YGR090W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Involved in rRNA processing and tRNA export from nucleus. Located in nucleolus. Part of CURI complex; UTP-C complex; and small-subunit processome. Orthologous to human NOL6 (nucleolar protein 6). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See UTP22 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (662358..666071)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Thr Neighboring gene U4/U6-U5 snRNP complex subunit PRP31 Neighboring gene serine/threonine-protein kinase DBF2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Utp22p acts in concert with Utp8p to channel aminoacyl-tRNA from the nucleolus to the nuclear tRNA export receptor Los1p but not Msn5p. Eswara MB, et al. Biochem Cell Biol, 2012 Dec. PMID 23194188
    2. Potential interface between ribosomal protein production and pre-rRNA processing. Rudra D, et al. Mol Cell Biol, 2007 Jul. PMID 17452446, Free PMC Article
    3. A Conserved Deubiquitinating Enzyme Uses Intrinsically Disordered Regions to Scaffold Multiple Protein Interaction Sites. Reed BJ, et al. J Biol Chem, 2015 Aug 14. PMID 26149687, Free PMC Article
    4. Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1. Downey M, et al. Curr Biol, 2013 Sep 9. PMID 23973296, Free PMC Article
    5. The nucleolar protein Nop19p interacts preferentially with Utp25p and Dhr2p and is essential for the production of the 40S ribosomal subunit in Saccharomyces cerevisiae. Choque E, et al. RNA Biol, 2011 Nov-Dec. PMID 21941128, Free PMC Article

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A dynamic Ifh1-Utp22 interaction fine-tunes ribosomal protein gene (RPG) expression to coordinate RPG and rRNA transcription.
      Title: A Molecular Titration System Coordinates Ribosomal Protein Gene Transcription with Ribosomal RNA Synthesis.
    2. data suggest that Utp22p recruits Utp8p to aminoacyl-tRNA synthetases in the nucleolus to collect aminoacyl-tRNA
      Title: Utp22p acts in concert with Utp8p to channel aminoacyl-tRNA from the nucleolus to the nuclear tRNA export receptor Los1p but not Msn5p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    part_of CURI complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CURI complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of UTP-C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of UTP-C complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rRNA-processing protein UTP22
    NP_011604.3
    • Component of the small-subunit processome; required for nuclear export of tRNAs; forms a complex with Rrp7p; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      662358..666071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181219.3 → NP_011604.3  TPA: rRNA-processing protein UTP22 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011604.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUM2, P53254
      UniProtKB/TrEMBL
      C7GWX3, C8Z8Y4
      Conserved Domains (6) summary
      pfam03813
      Location:203 → 355
      Nrap; Nrap protein domain 1
      pfam17403
      Location:358 → 514
      Nrap_D2; Nrap protein PAP/OAS-like domain
      pfam17404
      Location:519 → 691
      Nrap_D3; Nrap protein domain 3
      pfam17405
      Location:704 → 904
      Nrap_D4; Nrap protein nucleotidyltransferase domain 4
      pfam17406
      Location:906 → 1091
      Nrap_D5; Nrap protein PAP/OAS1-like domain 5
      pfam17407
      Location:1093 → 1231
      Nrap_D6; Nrap protein domain 6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53254.1

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