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    YCH1 phosphatase YCH1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853117, updated on 17-May-2024

    Summary

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    Gene symbol
    YCH1
    Gene description
    phosphatase YCH1
    Primary source
    FungiDB:YGR203W
    Locus tag
    YGR203W
    See related
    SGD:S000003435; AllianceGenome:SGD:S000003435; VEuPathDB:YGR203W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphatase activity and thiosulfate sulfurtransferase activity. Involved in dephosphorylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YCH1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (905237..905683)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene choline-phosphate cytidylyltransferase Neighboring gene trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of Saccharomyces cerevisiae Ygr203w, a homolog of single-domain rhodanese and Cdc25 phosphatase catalytic domain. Yeo HK, et al. Proteins, 2009 Aug 1. PMID 19382206
    2. Crystallization and preliminary X-ray diffraction analysis of Saccharomyces cerevisiae Ygr203p, a homologue of Acr2 arsenate reductase. Moon J, et al. Acta Crystallogr D Biol Crystallogr, 2000 Jun. PMID 10818363
    3. Protein tyrosine phosphatases: mechanisms of catalysis and regulation. Denu JM, et al. Curr Opin Chem Biol, 1998 Oct. PMID 9818190
    4. A small CDC25 dual-specificity tyrosine-phosphatase isoform in Arabidopsis thaliana. Landrieu I, et al. Proc Natl Acad Sci U S A, 2004 Sep 7. PMID 15329414, Free PMC Article
    5. Purification and characterization of ACR2p, the Saccharomyces cerevisiae arsenate reductase. Mukhopadhyay R, et al. J Biol Chem, 2000 Jul 14. PMID 10801893

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structure of Saccharomyces cerevisiae Ygr203w, a homolog of single-domain rhodanese and Cdc25 phosphatase catalytic domain.
      Title: Crystal structure of Saccharomyces cerevisiae Ygr203w, a homolog of single-domain rhodanese and Cdc25 phosphatase catalytic domain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiosulfate sulfurtransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatase YCH1
    NP_011719.1
    • Phosphatase with sequence similarity to Mih1p; member of the Cdc25p subfamily of tyrosine phosphatases and Arr2p, an arsenate reductase, based on the presence of a rhodanese-homology domain; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      905237..905683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181332.1 → NP_011719.1  TPA: phosphatase YCH1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011719.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUY5, P42937
      UniProtKB/TrEMBL
      A0A6A5PXC8, A6ZUL3, B3LI34, C8Z995, G2WET1, N1P4A0
      Conserved Domains (1) summary
      cd01531
      Location:9 → 132
      Acr2p; Eukaryotic arsenate resistance proteins are members of the Rhodanese Homology Domain superfamily. Included in this CD is the Saccharomyces cerevisiae arsenate reductase protein, Acr2p, and other yeast and plant homologs.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42937.1

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