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    MPC3 mitochondrial pyruvate carrier [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853158, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MPC3
    Official Full Name
    mitochondrial pyruvate carrier
    Primary source
    SGD:S000003475
    Locus tag
    YGR243W
    See related
    AllianceGenome:SGD:S000003475; FungiDB:YGR243W; VEuPathDB:YGR243W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FMP43
    Summary
    Enables pyruvate transmembrane transporter activity. Involved in mitochondrial pyruvate transmembrane transport. Located in mitochondrial membrane. Orthologous to human MPC2 (mitochondrial pyruvate carrier 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MPC3 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (977336..977776)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Yap1802p Neighboring gene succinate--CoA ligase (GDP-forming) subunit beta Neighboring gene Sda1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast biological networks unfold the interplay of antioxidants, genome and phenotype, and reveal a novel regulator of the oxidative stress response. Otero JM, et al. PLoS One, 2010 Oct 25. PMID 21049050, Free PMC Article
    2. The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state. Tavoulari S, et al. EMBO J, 2019 May 15. PMID 30979775, Free PMC Article
    3. Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes. Bender T, et al. EMBO J, 2015 Apr 1. PMID 25672363, Free PMC Article
    4. Methionine supplementation stimulates mitochondrial respiration. Tripodi F, et al. Biochim Biophys Acta Mol Cell Res, 2018 Dec. PMID 30290237
    5. Differential regulation of mitochondrial pyruvate carrier genes modulates respiratory capacity and stress tolerance in yeast. Timón-Gómez A, et al. PLoS One, 2013. PMID 24244496, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MPC is a hetero-dimer, not a multimeric complex. When not engaged in hetero-dimers, the yeast Mpc proteins can also form homo-dimers that are, however, inactive.
      Title: The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state.
    2. while expression of Mpc1 is not dependent on the carbon source, expression of Mpc2 and Mpc3 is specific to fermentative or respiratory conditions, respectively. This gives rise to two alternative carrier complexes
      Title: Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes.
    3. study concludes that the mitochondrial pyruvate carrier is composed of Mpc1(Ygl080w) and either Mpc2 (Yhr162w) or Mpc3 (Ygr243w); members of the MPC family were found in the inner mitochondrial membrane; mutants lacking MPC proteins showed severe defects in mitochondrial pyruvate uptake
      Title: Identification and functional expression of the mitochondrial pyruvate carrier.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables pyruvate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyruvate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pyruvate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial pyruvate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial pyruvate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial pyruvate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial pyruvate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial pyruvate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial pyruvate carrier
    NP_011759.1
    • Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on nonfermentable carbon sources, and heterodimerizes with Mpc1p to form the respiratory isoform of MPC; MPC localizes to the mitochondrial inner membrane and mediates pyruvate uptake; MPC3 paralog, MPC2, heterodimerizes with Mpc1p to form the fermentative MPC isoform; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      977336..977776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181372.1 → NP_011759.1  TPA: mitochondrial pyruvate carrier [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011759.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV23, P53311
      UniProtKB/TrEMBL
      A6ZUQ1, B3LHZ7, C7GNI6, C8Z9D5, G2WEW9, N1P4E5
      Conserved Domains (1) summary
      pfam03650
      Location:9 → 118
      MPC; Uncharacterized protein family (UPF0041)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53311.1

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