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    CPD1 2',3'-cyclic-nucleotide 3'-phosphodiesterase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853162, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CPD1
    Official Full Name
    2',3'-cyclic-nucleotide 3'-phosphodiesterase
    Primary source
    SGD:S000003479
    Locus tag
    YGR247W
    See related
    AllianceGenome:SGD:S000003479; FungiDB:YGR247W; VEuPathDB:YGR247W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Involved in cyclic nucleotide metabolic process. Colocalizes with clathrin-coated vesicle. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CPD1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (984966..985685)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Sda1p Neighboring gene transcription factor TFIIIB subunit BRF1 Neighboring gene 6-phosphogluconolactonase SOL4 Neighboring gene Mga1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the Saccharomyces cerevisiae cyclic nucleotide phosphodiesterase involved in the metabolism of ADP-ribose 1",2"-cyclic phosphate. Nasr F, et al. Nucleic Acids Res, 2000 Apr 15. PMID 10734185, Free PMC Article
    2. Biophysical characterization of cyclic nucleotide phosphodiesterases. Hofmann A, et al. Biochem Biophys Res Commun, 2002 Mar 8. PMID 11866446
    3. A highly specific phosphatase that acts on ADP-ribose 1''-phosphate, a metabolite of tRNA splicing in Saccharomyces cerevisiae. Shull NP, et al. Nucleic Acids Res, 2005. PMID 15684411, Free PMC Article
    4. A biochemical genomics approach for identifying genes by the activity of their products. Martzen MR, et al. Science, 1999 Nov 5. PMID 10550052
    5. Toolbox: Creating a systematic database of secretory pathway proteins uncovers new cargo for COPI. Weill U, et al. Traffic, 2018 May. PMID 29527758, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cyclic nucleotide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cyclic nucleotide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle HDA PubMed 

    General protein information

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    Preferred Names
    2',3'-cyclic-nucleotide 3'-phosphodiesterase
    NP_011763.1
    • Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      984966..985685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181376.1 → NP_011763.1  TPA: 2',3'-cyclic-nucleotide 3'-phosphodiesterase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011763.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV27, P53314
      UniProtKB/TrEMBL
      G2WEX3
      Conserved Domains (1) summary
      pfam07823
      Location:1 → 239
      CPDase; Cyclic phosphodiesterase-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53314.1

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