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    CHM7 Chm7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853398, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CHM7
    Official Full Name
    Chm7p
    Primary source
    SGD:S000003585
    Locus tag
    YJL049W
    See related
    AllianceGenome:SGD:S000003585; FungiDB:YJL049W; VEuPathDB:YJL049W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphatidic acid binding activity. Involved in nuclear pore complex assembly. Is active in nuclear inner membrane. Orthologous to human CHMP7 (charged multivesicular body protein 7). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See CHM7 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (345973..347325)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Irc8p Neighboring gene ATP-dependent RNA helicase MTR4 Neighboring gene Ubx6p Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Direct binding of ESCRT protein Chm7 to phosphatidic acid-rich membranes at nuclear envelope herniations. Thaller DJ, et al. J Cell Biol, 2021 Mar 1. PMID 33464310, Free PMC Article
    2. Comprehensive analysis of yeast ESCRT-III composition in single ESCRT-III deletion mutants. Heinzle C, et al. Biochem J, 2019 Jul 24. PMID 31273031
    3. ESCRT recruitment by the S. cerevisiae inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing. Capella M, et al. J Cell Sci, 2020 Dec 21. PMID 33262311
    4. Interactions in the ESCRT-III network of the yeast Saccharomyces cerevisiae. Brune T, et al. Curr Genet, 2019 Apr. PMID 30506264
    5. The ESCRT-III complex is required for nuclear pore complex sequestration and regulates gamete replicative lifespan in budding yeast meiosis. Koch BA, et al. Nucleus, 2020 Dec. PMID 32893723, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chm7 recruitment to sites of nuclear pore complexes assembly is mediated by its ESCRT-II domain and the LAP2-emerin-MAN1 (LEM) family of integral inner nuclear membrane proteins, Heh1 and Heh2.
      Title: Chm7 and Heh1 collaborate to link nuclear pore complex quality control with nuclear envelope sealing.
    2. Chm7 performs a novel function at the endosomal reticulum as part of an alternative ESCRT-III complex
      Title: Evidence for a Nonendosomal Function of the Saccharomyces cerevisiae ESCRT-III-Like Protein Chm7.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear pore complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle budding from membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Chm7p
    NP_012486.3
    • Phosphatidic acid (PA)-binding nuclear envelope (NE)-specific ESCRT; homolog of human CHMP7, localizes to the endoplasmic reticulum presumably as part of ESCRT-III like complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      345973..347325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181482.3 → NP_012486.3  TPA: Chm7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012486.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWD4, P47048
      UniProtKB/TrEMBL
      G2WGW8, N1P0W5
      Conserved Domains (1) summary
      cl21588
      Location:247 → 381
      Snf7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47048.1

    Gene LinkOut

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