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    MHO1 Mho1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853464, updated on 17-May-2024

    Summary

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    Gene symbol
    MHO1
    Gene description
    Mho1p
    Primary source
    FungiDB:YJR008W
    Locus tag
    YJR008W
    See related
    SGD:S000003768; AllianceGenome:SGD:S000003768; VEuPathDB:YJR008W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Located in cytoplasm and nucleus. Orthologous to human MEMO1 (mediator of cell motility 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MHO1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (452430..453446)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene DNA-directed DNA polymerase delta subunit POL31 Neighboring gene translation initiation factor eIF2 subunit alpha Neighboring gene glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 Neighboring gene sulfate adenylyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MHO1, an evolutionarily conserved gene, is synthetic lethal with PLC1; Mho1p has a role in invasive growth. Schlatter ID, et al. PLoS One, 2012. PMID 22412880, Free PMC Article
    2. Genomic expression programs in the response of yeast cells to environmental changes. Gasch AP, et al. Mol Biol Cell, 2000 Dec. PMID 11102521, Free PMC Article
    3. Genome expression analysis in yeast reveals novel transcriptional regulation by inositol and choline and new regulatory functions for Opi1p, Ino2p, and Ino4p. Santiago TC, et al. J Biol Chem, 2003 Oct 3. PMID 12871953
    4. Response of genes associated with mitochondrial function to mild heat stress in yeast Saccharomyces cerevisiae. Sakaki K, et al. J Biochem, 2003 Sep. PMID 14561723
    5. Large-scale analysis of yeast filamentous growth by systematic gene disruption and overexpression. Jin R, et al. Mol Biol Cell, 2008 Jan. PMID 17989363, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mho1p
    NP_012541.1
    • hypothetical protein; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      452430..453446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181665.1 → NP_012541.1  TPA: Mho1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012541.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWI3, P47085
      UniProtKB/TrEMBL
      A0A8H4F9D7, A6ZPX5, B3LQA7, B5VLH5, C7GUT3, N1P104
      Conserved Domains (1) summary
      pfam01875
      Location:5 → 334
      Memo; Memo-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47085.1

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