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    AVT3 Avt3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853710, updated on 2-Nov-2024

    Summary

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    Official Symbol
    AVT3
    Official Full Name
    Avt3p
    Primary source
    SGD:S000001629
    Locus tag
    YKL146W
    See related
    AllianceGenome:SGD:S000001629; FungiDB:YKL146W; VEuPathDB:YKL146W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables L-glutamine transmembrane transporter activity; L-isoleucine transmembrane transporter activity; and L-tyrosine transmembrane transporter activity. Involved in amino acid transmembrane export from vacuole and proline transport. Located in fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See AVT3 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (171783..173861)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene RNA lariat debranching enzyme Neighboring gene succinate dehydrogenase flavoprotein subunit SDH1 Neighboring gene proteasome regulatory particle base subunit RPT1 Neighboring gene DNA-directed RNA polymerase III subunit RPC25

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vacuolar transporter Avt4 is involved in excretion of basic amino acids from the vacuoles of Saccharomyces cerevisiae. Sekito T, et al. Biosci Biotechnol Biochem, 2014. PMID 25036121
    2. Genome-wide screening to study breeding methods to improve the nitrogen accumulation ability of yeast without gene recombinant techniques. Watanabe T, et al. Biosci Biotechnol Biochem, 2013. PMID 23649250
    3. Characterization of Avt1p as a vacuolar proton/amino acid antiporter in Saccharomyces cerevisiae. Tone J, et al. Biosci Biotechnol Biochem, 2015. PMID 25747199
    4. A vacuolar membrane protein Avt7p is involved in transport of amino acid and spore formation in Saccharomyces cerevisiae. Tone J, et al. Biosci Biotechnol Biochem, 2015. PMID 25266154
    5. A family of yeast proteins mediating bidirectional vacuolar amino acid transport. Russnak R, et al. J Biol Chem, 2001 Jun 29. PMID 11274162

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-glutamine transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables L-glutamine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-isoleucine transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables L-isoleucine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-tyrosine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-tyrosine transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables L-tyrosine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane export from vacuole IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in amino acid transmembrane export from vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in branched-chain amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tyrosine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in fungal-type vacuole membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Avt3p
    NP_012776.1
    • Vacuolar transporter; exports large neutral amino acids from vacuole; targeted to vacuole via AP-3 pathway; member of family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      171783..173861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179712.1 → NP_012776.1  TPA: Avt3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012776.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX50, P36062
      UniProtKB/TrEMBL
      A6ZZH5, C7GSN7, N1P8B6
      Conserved Domains (1) summary
      pfam01490
      Location:295 → 687
      Aa_trans; Transmembrane amino acid transporter protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36062.1

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