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    BPT1 ATP-binding cassette bilirubin transporter BPT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850645, updated on 17-May-2024

    Summary

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    Gene symbol
    BPT1
    Gene description
    ATP-binding cassette bilirubin transporter BPT1
    Primary source
    FungiDB:YLL015W
    Locus tag
    YLL015W
    See related
    SGD:S000003938; AllianceGenome:SGD:S000003938; VEuPathDB:YLL015W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables bilirubin transmembrane transporter activity and cadmium ion transmembrane transporter activity. Involved in bilirubin transport; cadmium ion transport; and vacuole fusion, non-autophagic. Located in fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in arterial calcification of infancy; coronary artery disease; and pseudoxanthoma elasticum. Orthologous to human ABCC6 (ATP binding cassette subfamily C member 6). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See BPT1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (116432..121111)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene Emc6p Neighboring gene mRNA-binding protein PUF3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ATP-binding cassette (ABC) transporter Bpt1p mediates vacuolar sequestration of glutathione conjugates in yeast. Klein M, et al. FEBS Lett, 2002 Jun 5. PMID 12044871
    2. Localization, regulation, and substrate transport properties of Bpt1p, a Saccharomyces cerevisiae MRP-type ABC transporter. Sharma KG, et al. Eukaryot Cell, 2002 Jun. PMID 12455987, Free PMC Article
    3. Abc protein transport of MRI contrast agents in canalicular rat liver plasma vesicles and yeast vacuoles. Pascolo L, et al. Biochem Biophys Res Commun, 2001 Mar 23. PMID 11263971
    4. The products of YCF1 and YLL015w (BPT1) cooperate for the ATP-dependent vacuolar transport of unconjugated bilirubin in Saccharomyces cerevisiae. Petrovic S, et al. Yeast, 2000 Apr. PMID 10790694
    5. Chaperonin point mutation enhances cadmium endurance in Saccharomyces cerevisiae. Dube A, et al. Biotechnol Lett, 2021 Sep. PMID 34047865

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chaperonin point mutation enhances cadmium endurance in Saccharomyces cerevisiae.
      Title: Chaperonin point mutation enhances cadmium endurance in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bilirubin transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables bilirubin transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cadmium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bilirubin transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in bilirubin transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cadmium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cadmium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuole fusion, non-autophagic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette bilirubin transporter BPT1
    NP_013086.1
    • ABC type transmembrane transporter of MRP/CFTR family; found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      116432..121111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181835.1 → NP_013086.1  TPA: ATP-binding cassette bilirubin transporter BPT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013086.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXY7, P14772
      UniProtKB/TrEMBL
      A0A8H4BZ72, B5VMT0, C8ZCV8, N1NZV6
      Conserved Domains (1) summary
      TIGR00957
      Location:222 → 1556
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14772.2

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