ALT1 alanine transaminase ALT1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: ALT1
Official Full Name: alanine transaminase ALT1
Primary source: SGD:S000004079
Locus tag: YLR089C
See related: AllianceGenome:SGD:S000004079; FungiDB:YLR089C; VEuPathDB:YLR089C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables L-alanine:2-oxoglutarate aminotransferase activity and pyridoxal phosphate binding activity. Involved in alanine biosynthetic process and alanine catabolic process. Is active in mitochondrion. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spastic paraplegia and microcephaly. Orthologous to several human genes including GPT (glutamic--pyruvic transaminase). [provided by Alliance of Genome Resources, Oct 2024]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

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Alanine-metabolizing enzyme Alt1 is critical in determining yeast life span.
Title: Alanine-metabolizing enzyme Alt1 is critical in determining yeast life span, as revealed by combined metabolomic and genetic studies.
Paralogous ALT1 and ALT2 retention and diversification have generated catalytically active and inactive aminotransferases in Saccharomyces cerevisiae
Title: Paralogous ALT1 and ALT2 retention and diversification have generated catalytically active and inactive aminotransferases in Saccharomyces cerevisiae.
It can thus be concluded that ALT1 has functions in alanine biosynthesis and utilization or only alanine utilization under respiratory and fermentative conditions.
Title: ALT1-encoded alanine aminotransferase plays a central role in the metabolism of alanine in Saccharomyces cerevisiae.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables L-alanine:2-oxoglutarate aminotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-alanine:2-oxoglutarate aminotransferase activity	IEA Inferred from Electronic Annotation more info
enables L-alanine:2-oxoglutarate aminotransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pyridoxal phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-alanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in alanine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in alanine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_013190.1

Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthesis and catabolism; TOR1-independent role in determining chronological lifespan; expression is induced in the presence of alanine; repression is mediated by Nrg1p; ALT1 has a paralog, ALT2, that arose from the whole genome duplication; Alt2p is catalytically inactive