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    TML25 palmitoyl-(protein) hydrolase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850809, updated on 28-Oct-2024

    Summary

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    Official Symbol
    TML25
    Official Full Name
    palmitoyl-(protein) hydrolase
    Primary source
    SGD:S000004108
    Locus tag
    YLR118C
    See related
    AllianceGenome:SGD:S000004108; FungiDB:YLR118C; VEuPathDB:YLR118C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    APT1
    Summary
    Enables palmitoyl-(protein) hydrolase activity. Involved in protein deacylation. Located in cytoplasm and nucleus. Orthologous to several human genes including LYPLA1 (lysophospholipase 1). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See TML25 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (384725..385408, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene mRNA splicing protein MSL5 Neighboring gene Clf1p Neighboring gene ESCRT-I subunit protein SRN2 Neighboring gene aspartyl protease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Saccharomyces cerevisiae acyl-protein thioesterase 1, the enzyme responsible for G protein alpha subunit deacylation in vivo. Duncan JA, et al. J Biol Chem, 2002 Aug 30. PMID 12080046
    2. Sequence analysis of a 37.6 kbp cosmid clone from the right arm of Saccharomyces cerevisiae chromosome XII, carrying YAP3, HOG1, SNR6, tRNA-Arg3 and 23 new open reading frames, among which several homologies to proteins involved in cell division control and to mammalian growth factors and other animal proteins are found. Verhasselt P, et al. Yeast, 1997 Mar 15. PMID 9090053
    3. Global protein expression profiling of budding yeast in response to DNA damage. Lee MW, et al. Yeast, 2007 Mar. PMID 17351896
    4. Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale. Morgenstern M, et al. Cell Rep, 2017 Jun 27. PMID 28658629, Free PMC Article
    5. Saccharomyces cerevisiae Is Dependent on Vesicular Traffic between the Golgi Apparatus and the Vacuole When Inositolphosphorylceramide Synthase Aur1 Is Inactivated. Voynova NS, et al. Eukaryot Cell, 2015 Dec. PMID 26432633, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables palmitoyl-(protein) hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macromolecule depalmitoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein deacylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein depalmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyl-(protein) hydrolase
    NP_013219.1
    • Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      384725..385408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182005.1 → NP_013219.1  TPA: palmitoyl-(protein) hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013219.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYB6, Q12354
      UniProtKB/TrEMBL
      A7A120, B3LT83, B5VN54, C7GQD3, C8ZD88, G2WIW0, N1P6L9
      Conserved Domains (1) summary
      pfam02230
      Location:1 → 225
      Abhydrolase_2; Phospholipase/Carboxylesterase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12354.1

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