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    TSR2 Tsr2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851154, updated on 17-May-2024

    Summary

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    Gene symbol
    TSR2
    Gene description
    Tsr2p
    Primary source
    FungiDB:YLR435W
    Locus tag
    YLR435W
    See related
    SGD:S000004427; AllianceGenome:SGD:S000004427; VEuPathDB:YLR435W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ribosome binding activity. Involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleus. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 14 with mandibulofacial dysostosis. Orthologous to human TSR2 (TSR2 ribosome maturation factor). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TSR2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (1006378..1006995)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene IMP dehydrogenase IMD3 Neighboring gene calcineurin catalytic subunit A Neighboring gene Ecm30p Neighboring gene Dif1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2. Schütz S, et al. Nat Commun, 2018 Sep 10. PMID 30201955, Free PMC Article
    2. Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness. Tye BW, et al. Elife, 2019 Mar 7. PMID 30843788, Free PMC Article
    3. A RanGTP-independent mechanism allows ribosomal protein nuclear import for ribosome assembly. Schütz S, et al. Elife, 2014 Aug 21. PMID 25144938, Free PMC Article
    4. ER cargo properties specify a requirement for COPII coat rigidity mediated by Sec13p. Copic A, et al. Science, 2012 Mar 16. PMID 22300850, Free PMC Article
    5. Prefabrication of a ribosomal protein subcomplex essential for eukaryotic ribosome formation. Peña C, et al. Elife, 2016 Dec 8. PMID 27929371, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A conserved nuclear carrier Tsr2 coordinates transfer of the ribosomal protein eS26 to the earliest assembling pre-ribosome, the 90S.
      Title: A RanGTP-independent mechanism allows ribosomal protein nuclear import for ribosome assembly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tsr2p
    NP_013539.4
    • Protein with a potential role in pre-rRNA processing

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      1006378..1006995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182323.3 → NP_013539.4  TPA: Tsr2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013539.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ69, Q06672
      UniProtKB/TrEMBL
      A0A8H4BXP8, B3RHU3, C7GSM1
      Conserved Domains (1) summary
      pfam10273
      Location:32 → 110
      WGG; Pre-rRNA-processing protein TSR2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06672.2

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