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    VPS20 ESCRT-III subunit protein VPS20 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855101, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VPS20
    Official Full Name
    ESCRT-III subunit protein VPS20
    Primary source
    SGD:S000004682
    Locus tag
    YMR077C
    See related
    AllianceGenome:SGD:S000004682; FungiDB:YMR077C; VEuPathDB:YMR077C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CHM6; VPL10; VPT20
    Summary
    Involved in ATP export; intralumenal vesicle formation; and late endosome to vacuole transport. Located in endoplasmic reticulum. Part of ESCRT III complex. Orthologous to human CHMP6 (charged multivesicular body protein 6). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See VPS20 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (421484..422149, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Pds5p Neighboring gene tRNA-Val Neighboring gene Ctf18p Neighboring gene phosphatidylinositol/phosphatidylcholine transfer protein SEC14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional reconstitution of ESCRT-III assembly and disassembly. Saksena S, et al. Cell, 2009 Jan 9. PMID 19135892, Free PMC Article
    2. The crystal structure of the C-terminal domain of Vps28 reveals a conserved surface required for Vps20 recruitment. Pineda-Molina E, et al. Traffic, 2006 Aug. PMID 16749904
    3. Regulation of yeast ESCRT-III membrane scission activity by the Doa4 ubiquitin hydrolase. Johnson N, et al. Mol Biol Cell, 2017 Mar 1. PMID 28057764, Free PMC Article
    4. Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae. Yeo SC, et al. J Cell Sci, 2003 Oct 1. PMID 12953057
    5. Structural Fine-Tuning of MIT-Interacting Motif 2 (MIM2) and Allosteric Regulation of ESCRT-III by Vps4 in Yeast. Kojima R, et al. J Mol Biol, 2016 Jun 5. PMID 27075672

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Binding of Vps20 to the Doa4 N-terminus inhibits a non-catalytic function of Doa4 that promotes ILV formation.
      Title: Doa4 function in ILV budding is restricted through its interaction with the Vps20 subunit of ESCRT-III.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP export IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intralumenal vesicle formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intralumenal vesicle formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle budding from membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ESCRT-III subunit protein VPS20
    NP_013794.1
    • Myristoylated subunit of the ESCRT-III complex; the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      421484..422149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182576.1 → NP_013794.1  TPA: ESCRT-III subunit protein VPS20 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013794.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZQ1, Q04272
      UniProtKB/TrEMBL
      A6ZMD6, B3LLX0, B5VPK3, C7GL47, C8ZET0, G2WKC5, N1P095
      Conserved Domains (1) summary
      pfam03357
      Location:15 → 186
      Snf7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04272.3

    Gene LinkOut

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