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    UTP15 snoRNA-binding rRNA-processing protein UTP15 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855118, updated on 7-Jul-2024

    Summary

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    Gene symbol
    UTP15
    Gene description
    snoRNA-binding rRNA-processing protein UTP15
    Primary source
    FungiDB:YMR093W
    Locus tag
    YMR093W
    See related
    SGD:S000004699; AllianceGenome:SGD:S000004699; VEuPathDB:YMR093W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables U3 snoRNA binding activity. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and positive regulation of transcription by RNA polymerase I. Located in nucleolus and rDNA heterochromatin. Part of small-subunit processome and t-UTP complex. Orthologous to human UTP15 (UTP15 small subunit processome component). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See UTP15 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (454015..455556)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Npl6p Neighboring gene Aip1p Neighboring gene Ctf13p Neighboring gene putative pyridoxal 5'-phosphate synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interactions show the importance of rRNA modification machinery for the role of Rps15p during ribosome biogenesis in S. cerevisiae. Bellemer C, et al. PLoS One, 2010 May 3. PMID 20454621, Free PMC Article
    2. The C-terminus of Utp4, mutated in childhood cirrhosis, is essential for ribosome biogenesis. Freed EF, et al. Nucleic Acids Res, 2010 Aug. PMID 20385600, Free PMC Article
    3. Proteins and RNA sequences required for the transition of the t-Utp complex into the SSU processome. Gallagher JEG. FEMS Yeast Res, 2019 Jan 1. PMID 30445532, Free PMC Article
    4. In vitro reconstitution of yeast tUTP/UTP A and UTP B subcomplexes provides new insights into their modular architecture. Pöll G, et al. PLoS One, 2014. PMID 25501974, Free PMC Article
    5. The telomerase inhibitor Gno1p/PINX1 activates the helicase Prp43p during ribosome biogenesis. Chen YL, et al. Nucleic Acids Res, 2014 Jun. PMID 24823796, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables U3 snoRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of rDNA heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of t-UTP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    snoRNA-binding rRNA-processing protein UTP15
    NP_013811.1
    • Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      454015..455556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182593.1 → NP_013811.1  TPA: snoRNA-binding rRNA-processing protein UTP15 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013811.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZR6, Q04305
      UniProtKB/TrEMBL
      A0A6A5PPN4, A6ZMF0, B3LLY4, B5VPM0, C8ZEU5, G2WKE1, N1NYC0
      Conserved Domains (3) summary
      sd00039
      Location:84 → 122
      7WD40; WD40 repeat [structural motif]
      pfam09384
      Location:365 → 511
      UTP15_C; UTP15 C terminal
      cl29593
      Location:36 → 311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04305.1

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