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    NDE1 NADH-ubiquinone reductase (H(+)-translocating) NDE1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855176, updated on 28-Oct-2024

    Summary

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    Official Symbol
    NDE1
    Official Full Name
    NADH-ubiquinone reductase (H(+)-translocating) NDE1
    Primary source
    SGD:S000004753
    Locus tag
    YMR145C
    See related
    AllianceGenome:SGD:S000004753; FungiDB:YMR145C; VEuPathDB:YMR145C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NDH1
    Summary
    Enables NADH dehydrogenase activity. Involved in NADH oxidation; glycolytic fermentation to ethanol; and regulation of apoptotic process. Located in mitochondrial membrane. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See NDE1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (554793..556475, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S16A Neighboring gene Fdo1p Neighboring gene translation initiation factor eIF3 subunit i Neighboring gene Ldo45p Neighboring gene Ldo16p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A chemical genetic screen for modulators of asymmetrical 2,2'-dimeric naphthoquinones cytotoxicity in yeast. Emadi A, et al. PLoS One, 2010 May 26. PMID 20520766, Free PMC Article
    2. Mitochondrial NADH dehydrogenase activity and ability to tolerate acetaldehyde determine faster ethanol production in Saccharomyces cerevisiae. Shankar CS, et al. Biochem Mol Biol Int, 1996 Sep. PMID 8886280
    3. The Saccharomyces cerevisiae NDE1 and NDE2 genes encode separate mitochondrial NADH dehydrogenases catalyzing the oxidation of cytosolic NADH. Luttik MA, et al. J Biol Chem, 1998 Sep 18. PMID 9733747
    4. Characterization of the second external alternative dehydrogenase from mitochondria of the respiratory yeast Kluyveromyces lactis. Tarrío N, et al. Biochim Biophys Acta, 2006 Nov. PMID 17052684
    5. Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging. Li W, et al. Mol Biol Cell, 2006 Apr. PMID 16436509, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In the current investigation the relationship between ROS production and MMP was studied in respiring yeast cells in stationary phase, using diphenyleneiodonium chloride (DPI), an inhibitor of flavin-containing proteins, as well as the mutants deleted for NDE1, NDE2 and NDI1 genes, encoding flavin-containing external and internal NADH dehydrogenases.
      Title: The role of flavin-containing enzymes in mitochondrial membrane hyperpolarization and ROS production in respiring Saccharomyces cerevisiae cells under heat-shock conditions.
    2. impairment in the oxidation of cytosolic NADH by Nde1p is deleterious towards mitochondrial biogenesis due to an increase in reactive oxygen species release
      Title: nde1 deletion improves mitochondrial DNA maintenance in Saccharomyces cerevisiae coenzyme Q mutants.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables NADH dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADH dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH:ubiquinone reductase (non-electrogenic) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADH oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADH oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in NADH oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic fermentation to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADH-ubiquinone reductase (H(+)-translocating) NDE1
    NP_013865.1
    • Mitochondrial external NADH dehydrogenase; type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain; NDE1 has a paralog, NDE2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      554793..556475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182647.1 → NP_013865.1  TPA: NADH-ubiquinone reductase (H(+)-translocating) NDE1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013865.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZW7, P40215
      UniProtKB/TrEMBL
      A6ZMK4, B3LM33, B5VPS1, C7GQ85, C8ZF02, G2WKJ6, N1P0D9
      Conserved Domains (1) summary
      COG1252
      Location:110 → 559
      Ndh; NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40215.1

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