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    EOS1 Eos1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855644, updated on 29-Jun-2024

    Summary

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    Gene symbol
    EOS1
    Gene description
    Eos1p
    Primary source
    FungiDB:YNL080C
    Locus tag
    YNL080C
    See related
    SGD:S000005024; AllianceGenome:SGD:S000005024; VEuPathDB:YNL080C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in cellular response to oxidative stress and protein N-linked glycosylation. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See EOS1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (476932..478032, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ATP-binding mismatch repair protein Neighboring gene putative mitochondrial 37S ribosomal protein SWS2 Neighboring gene tropomyosin TPM1 Neighboring gene Nis1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EOS1, whose deletion confers sensitivity to oxidative stress, is involved in N-glycosylation in Saccharomyces cerevisiae. Nakamura T, et al. Biochem Biophys Res Commun, 2007 Feb 9. PMID 17187761
    2. Multicopy suppression of oxidant-sensitive eos1 mutation by IZH2 in Saccharomyces cerevisiae and the involvement of Eos1 in zinc homeostasis. Nakamura T, et al. FEMS Yeast Res, 2010 May. PMID 20146743
    3. Kinetochore genes are required to fully activate secretory pathway expansion in S. cerevisiae under induced ER stress. Low YS, et al. Mol Biosyst, 2014 Jul. PMID 24722431
    4. Genes involved in protein glycosylation determine the activity and cell internalization of the antifungal peptide PAF26 in Saccharomyces cerevisiae. Harries E, et al. Fungal Genet Biol, 2013 Sep-Oct. PMID 23942187
    5. Identification of gene products that control lipid droplet size in yeast using a high-throughput quantitative image analysis. Lv X, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Feb. PMID 30414449

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Double disruption of the EOS1 and IZH2 genes yielded a slow-growth phenotype, suggesting that the two proteins are involved in related cellular processes.
      Title: Multicopy suppression of oxidant-sensitive eos1 mutation by IZH2 in Saccharomyces cerevisiae and the involvement of Eos1 in zinc homeostasis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Eos1p
    NP_014319.1
    • Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      476932..478032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182918.1 → NP_014319.1  TPA: Eos1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014319.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W199, P53938, Q45TY2
      UniProtKB/TrEMBL
      A0A8H4FAU1, A6ZS00, B3LNT9, B5VQW3, C7GUN0, C8ZGF0, N1NZG6
      Conserved Domains (1) summary
      pfam12326
      Location:134 → 342
      EOS1; N-glycosylation protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53938.1

    Gene LinkOut

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