KRE33 ribosome biosynthesis protein KRE33 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: KRE33
Official Full Name: ribosome biosynthesis protein KRE33
Primary source: SGD:S000005076
Locus tag: YNL132W
See related: AllianceGenome:SGD:S000005076; FungiDB:YNL132W; VEuPathDB:YNL132W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RRA1
Summary: Enables rRNA cytidine N-acetyltransferase activity; snoRNA binding activity; and tRNA binding activity. Involved in mRNA modification and ribosomal small subunit biogenesis. Located in nucleolus. Part of 90S preribosome. Orthologous to human NAT10 (N-acetyltransferase 10). [provided by Alliance of Genome Resources, Oct 2024]
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Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Identification of Kre33 as responsible for both 18S rRNA and leucine/serine tRNA acetylation.
Title: Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1.
KRE3 (Rra1p) modulates biogenesis of the 40 S subunit by sensing nuclear acetyl-CoA concentration.
Title: A single acetylation of 18 S rRNA is essential for biogenesis of the small ribosomal subunit in Saccharomyces cerevisiae.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables rRNA cytidine N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA cytidine N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables snoRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables tRNA N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA modification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA acetylation involved in maturation of SSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA acetylation involved in maturation of SSU-rRNA	IEA Inferred from Electronic Annotation more info
involved_in rRNA modification	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in ribosomal small subunit biogenesis	IEA Inferred from Electronic Annotation more info
involved_in ribosomal small subunit biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA acetylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of 90S preribosome	HDA more info	PubMed
located_in nucleolus	HDA more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_014267.1

Acetyltransferase required for biogenesis of small ribosomal subunit; conserved 18S rRNA cytosine acetyltransferase that modifies tRNAs assisted by adaptor Tan1p; responsible for incorporation of N4-acetylcytidine into mRNAs; human homolog NAT10 implicated in several types of cancer and premature aging

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The following sections contain reference sequences that belong to a specific genome build. Explain