U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    IGO1 phosphatase regulator [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855565, updated on 17-May-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    IGO1
    Gene description
    phosphatase regulator
    Primary source
    FungiDB:YNL157W
    Locus tag
    YNL157W
    See related
    SGD:S000005101; AllianceGenome:SGD:S000005101; VEuPathDB:YNL157W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein serine/threonine phosphatase inhibitor activity. Involved in mRNA stabilization; positive regulation of cell cycle process; and regulation of cellular protein metabolic process. Located in P-body and nucleus. Orthologous to human ARPP19 (cAMP regulated phosphoprotein 19) and ENSA (endosulfine alpha). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See IGO1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (340352..340858)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Asi2p Neighboring gene Pga1p Neighboring gene Nsg2p Neighboring gene Cuz1p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A phosphatase-centric mechanism drives stress signaling response. Hollenstein DM, et al. EMBO Rep, 2021 Nov 4. PMID 34558777, Free PMC Article
    2. The Rim15-endosulfine-PP2ACdc55 signalling module regulates entry into gametogenesis and quiescence via distinct mechanisms in budding yeast. Sarkar S, et al. PLoS Genet, 2014 Jun. PMID 24968058, Free PMC Article
    3. Quantification of mRNA stability of stress-responsive yeast genes following conditional excision of open reading frames. Talarek N, et al. RNA Biol, 2013 Aug. PMID 23792549, Free PMC Article
    4. Yeast endosulfines control entry into quiescence and chronological life span by inhibiting protein phosphatase 2A. Bontron S, et al. Cell Rep, 2013 Jan 31. PMID 23273919
    5. Initiation of the yeast G0 program requires Igo1 and Igo2, which antagonize activation of decapping of specific nutrient-regulated mRNAs. Luo X, et al. RNA Biol, 2011 Jan-Feb. PMID 21289492

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We propose that the Rim15-Endosulfine( Igo1 and Igo2 )-PP2ACdc55 signalling module triggers entry into quiescence and gametogenesis by regulating dephosphorylation of distinct substrates
      Title: The Rim15-endosulfine-PP2ACdc55 signalling module regulates entry into gametogenesis and quiescence via distinct mechanisms in budding yeast.
    2. Igo1/Igo2 can inhibit Cdc55 in early mitosis, but their contribution to Cdc55 regulation is relatively minor compared with the role of Zds1/Zds2.
      Title: Comparative genetic analysis of PP2A-Cdc55 regulators in budding yeast.
    3. We conclude that Greatwall, endosulfines((Igo1 and Igo2), and PP2A are part of a regulatory module that has been conserved during evolution irrespective of PP2A function in the control of mitosis
      Title: Budding yeast greatwall and endosulfines control activity and spatial regulation of PP2A(Cdc55) for timely mitotic progression.
    4. The mRNA decapping pathway targets heat shock protein 26 (HSP26) mRNAs in the absence of Igo1 and Igo2.
      Title: Initiation of the yeast G0 program requires Igo1 and Igo2, which antagonize activation of decapping of specific nutrient-regulated mRNAs.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to heat IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA stabilization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of G1 to G0 transition IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cell cycle phase transition IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein dephosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    phosphatase regulator
    NP_014242.1
    • Protein required for initiation of the G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylation (S63) by Rim15p increases interaction with and inhibition of PP2A-Cdc55 for timely mitotic progression; can also activate PP2A-Cdc55 complexes and influence Cdc55p localization along with Igo2p; GFP protein localizes to the cytoplasm and nucleus; IGO1 has a paralog, IGO2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      340352..340858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182995.1 → NP_014242.1  TPA: phosphatase regulator [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014242.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W126, P53897
      UniProtKB/TrEMBL
      A0A6A5Q5E4, A6ZRS7, B3LP12, C7GXV7, C8ZG72, G2WLV0, N1NZA5
      Conserved Domains (1) summary
      pfam04667
      Location:27 → 109
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53897.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous