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    RIA1 GTPase RIA1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855558, updated on 28-Oct-2024

    Summary

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    Official Symbol
    RIA1
    Official Full Name
    GTPase RIA1
    Primary source
    SGD:S000005107
    Locus tag
    YNL163C
    See related
    AllianceGenome:SGD:S000005107; FungiDB:YNL163C; VEuPathDB:YNL163C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    EFL1
    Summary
    Enables GTPase activity. Involved in cytosolic ribosome assembly. Located in cytoplasm. Used to study Shwachman-Diamond syndrome. Human ortholog(s) of this gene implicated in Shwachman-Diamond syndrome. Orthologous to human EFL1 (elongation factor like GTPase 1). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See RIA1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (326741..330073, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ibd2p Neighboring gene uncharacterized protein Neighboring gene ribosomal 60S subunit protein L42A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism of eIF6-mediated inhibition of ribosomal subunit joining. Gartmann M, et al. J Biol Chem, 2010 May 14. PMID 20356839, Free PMC Article
    2. Cooperative energetic effects elicited by the yeast Shwachman-Diamond syndrome protein (Sdo1) and guanine nucleotides modulate the complex conformational landscape of the elongation factor-like 1 (Efl1) GTPase. Luviano A, et al. Biophys Chem, 2019 Apr. PMID 30780079
    3. Ria1p (Ynl163c), a protein similar to elongation factors 2, is involved in the biogenesis of the 60S subunit of the ribosome in Saccharomyces cerevisiae. Bécam AM, et al. Mol Genet Genomics, 2001 Nov. PMID 11713675
    4. Direct interaction between EFL1 and SBDS is mediated by an intrinsically disordered insertion domain. Asano N, et al. Biochem Biophys Res Commun, 2014 Jan 24. PMID 24406167
    5. The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast. Menne TF, et al. Nat Genet, 2007 Apr. PMID 17353896

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mutual effects of Sdo1 and nucleotides on Efl1 modulate in a very specific and robust way the complex conformational landscape of Efl1, resembling the behavior observed with other GTPases and their cofactors.
      Title: Cooperative energetic effects elicited by the yeast Shwachman-Diamond syndrome protein (Sdo1) and guanine nucleotides modulate the complex conformational landscape of the elongation factor-like 1 (Efl1) GTPase.
    2. Sdo1 appears to function within a pathway containing elongation factor-like 1, and together they control translational activation of ribosomes.
      Title: The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytosolic ribosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytosolic ribosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytosolic ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GTPase RIA1
    NP_014236.1
    • Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, a guanine nucleotide exchange factor (GEF), promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      326741..330073 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183001.1 → NP_014236.1  TPA: GTPase RIA1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014236.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W119, P53893
      UniProtKB/TrEMBL
      B3LP19, C7GTE0, E9PAB2, N1NXS8
      Conserved Domains (1) summary
      cl30786
      Location:1 → 1091
      FusA; Translation elongation factor EF-G, a GTPase [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53893.1

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