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    FMP40 Fmp40p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855879, updated on 28-Oct-2024

    Summary

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    Official Symbol
    FMP40
    Official Full Name
    Fmp40p
    Primary source
    SGD:S000006143
    Locus tag
    YPL222W
    See related
    AllianceGenome:SGD:S000006143; FungiDB:YPL222W; VEuPathDB:YPL222W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables AMPylase activity. Involved in cell redox homeostasis and protein adenylylation. Is active in mitochondrion. Orthologous to human SELENOO (selenoprotein O). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See FMP40 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (130162..132228)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Mmt2p Neighboring gene Gre1p Neighboring gene flavin adenine dinucleotide transporter Neighboring gene ribosomal 60S subunit protein L1A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae signature genes for predicting nitrogen deficiency during alcoholic fermentation. Mendes-Ferreira A, et al. Appl Environ Microbiol, 2007 Aug. PMID 17601813, Free PMC Article
    2. Acetaldehyde addition throughout the growth phase alleviates the phenotypic effect of zinc deficiency in Saccharomyces cerevisiae. Cheraiti N, et al. Appl Microbiol Biotechnol, 2008 Jan. PMID 17938904
    3. Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism. Yu R, et al. Nat Commun, 2021 Mar 31. PMID 33790287, Free PMC Article
    4. A Genetic Screen To Identify Genes Influencing the Secondary Redox Couple NADPH/NADP(+) in the Yeast Saccharomyces cerevisiae. Yadav S, et al. G3 (Bethesda), 2020 Jan 7. PMID 31757928, Free PMC Article
    5. Btn3 regulates the endosomal sorting function of the yeast Ent3 epsin, an adaptor for SNARE proteins. Morvan J, et al. J Cell Sci, 2015 Feb 15. PMID 25512335

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables AMPylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables AMPylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables AMPylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein adenylylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fmp40p
    NP_015102.1
    • Mitochondrial AMPylator in the pseudokinase selenoprotein-O family; role in the oxidative stress response, transferring AMP from ATP to protein substrates (AMPylation) involved in redox homeostasis; regulates S-glutathionylation levels; proposed involvement in the environmental stress response

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      130162..132228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184036.1 → NP_015102.1  TPA: Fmp40p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015102.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3E8, Q08968
      UniProtKB/TrEMBL
      A6ZW33, B3LKK8, B5VSV9, C7GN49, C8ZIF7, N1NWM1
      Conserved Domains (1) summary
      COG0397
      Location:29 → 688
      YdiU; Uncharacterized conserved protein YdiU, UPF0061 family [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08968.1

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