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    CHP1 ribosome-associated Tef1p biogenesis chaperone CHP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855876, updated on 7-Jul-2024

    Summary

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    Gene symbol
    CHP1
    Gene description
    ribosome-associated Tef1p biogenesis chaperone CHP1
    Primary source
    FungiDB:YPL225W
    Locus tag
    YPL225W
    See related
    SGD:S000006146; AllianceGenome:SGD:S000006146; VEuPathDB:YPL225W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Located in cytoplasm. Orthologous to human PBDC1 (polysaccharide biosynthesis domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CHP1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (126006..126446)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene dolichyl-phosphate beta-glucosyltransferase Neighboring gene New1p Neighboring gene Mmt2p Neighboring gene Gre1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Host factors that affect Ty3 retrotransposition in Saccharomyces cerevisiae. Aye M, et al. Genetics, 2004 Nov. PMID 15579677, Free PMC Article
    2. A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Brandman O, et al. Cell, 2012 Nov 21. PMID 23178123, Free PMC Article
    3. Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Fleischer TC, et al. Genes Dev, 2006 May 15. PMID 16702403, Free PMC Article
    4. Mapping the functional yeast ABC transporter interactome. Snider J, et al. Nat Chem Biol, 2013 Sep. PMID 23831759, Free PMC Article
    5. Genome-wide bimolecular fluorescence complementation analysis of SUMO interactome in yeast. Sung MK, et al. Genome Res, 2013 Apr. PMID 23403034, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables misfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nascent polypeptide-associated complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein folding chaperone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation elongation factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' cotranslational protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosome-associated Tef1p biogenesis chaperone CHP1
    NP_015099.1
    • Chaperone for eEF1A; ribosome-associated chaperone dedicated to facilitating high-level expression of eEF1A; transiently binds nascent GTPase domain of eEF1A as soon as it emerges from ribosome tunnel; forms complex with NAC by binding UBA domain of Egd2p; inactivation results in disturbed proteostasis and Hsf1p activation due to abberant eEF1A biogenesis; overlapping phenotypes support notion that Chp1p functions in same eEF1A biogenesis pathway as chaperone Zpr1p-Aim29p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      126006..126446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184039.1 → NP_015099.1  TPA: ribosome-associated Tef1p biogenesis chaperone CHP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015099.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3E5, Q08971
      UniProtKB/TrEMBL
      A0A6A5Q5V7, A6ZW30, B3LKK6, C7GU64, C8ZIF4, G2WNW0, N1NXX8
      Conserved Domains (1) summary
      pfam04669
      Location:15 → 142
      Polysacc_synt_4; Polysaccharide biosynthesis
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08971.1

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