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    HUT1 UDP-galactose transporter HUT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855832, updated on 28-Oct-2024

    Summary

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    Official Symbol
    HUT1
    Official Full Name
    UDP-galactose transporter HUT1
    Primary source
    SGD:S000006165
    Locus tag
    YPL244C
    See related
    AllianceGenome:SGD:S000006165; FungiDB:YPL244C; VEuPathDB:YPL244C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable UDP-galactose transmembrane transporter activity and UDP-glucose transmembrane transporter activity. Involved in UDP-galactose transmembrane transport and UDP-glucose transmembrane transport. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 26. Orthologous to several human genes including SLC35B1 (solute carrier family 35 member B1). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See HUT1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (87014..88033, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative rhomboid protease RBD2 Neighboring gene uncharacterized protein Neighboring gene signal recognition particle subunit SRP68 Neighboring gene Iqg1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of HUT1 gene stimulates in vivo galactosylation by enhancing UDP-galactose transport activity in Saccharomyces cerevisiae. Kainuma M, et al. Yeast, 2001 Apr. PMID 11284009
    2. Hut1 proteins identified in Saccharomyces cerevisiae and Schizosaccharomyces pombe are functional homologues involved in the protein-folding process at the endoplasmic reticulum. Nakanishi H, et al. Yeast, 2001 Apr. PMID 11284010
    3. Similarities between UDP-glucose and adenine nucleotide release in yeast: involvement of the secretory pathway. Esther CR Jr, et al. Biochemistry, 2008 Sep 2. PMID 18693752, Free PMC Article
    4. Loss of Cardiolipin Leads to Perturbation of Acetyl-CoA Synthesis. Raja V, et al. J Biol Chem, 2017 Jan 20. PMID 27941023, Free PMC Article
    5. Comprehensive and quantitative mapping of RNA-protein interactions across a transcribed eukaryotic genome. She R, et al. Proc Natl Acad Sci U S A, 2017 Apr 4. PMID 28325876, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables UDP-galactose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-galactose transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables UDP-glucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-galactose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-galactose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in UDP-glucose transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in UDP-glucose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-galactose transporter HUT1
    NP_015080.1
    • Protein with a role in UDP-galactose transport to the Golgi lumen; has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      87014..88033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184058.1 → NP_015080.1  TPA: UDP-galactose transporter HUT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015080.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3C7, Q12520
      UniProtKB/TrEMBL
      A6ZW12, B3LKI8, B5VSU0, C7GTQ1, C8ZID5, N1NVK1
      Conserved Domains (1) summary
      pfam08449
      Location:7 → 321
      UAA; UAA transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12520.1

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