ATG11 autophagy protein ATG11 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ATG11
Gene description: autophagy protein ATG11
Primary source: FungiDB:YPR049C
Locus tag: YPR049C
See related: SGD:S000006253; AllianceGenome:SGD:S000006253; VEuPathDB:YPR049C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CVT3; CVT9
Summary: Enables SNARE binding activity and molecular adaptor activity. Involved in several processes, including cytoplasm to vacuole transport by the Cvt pathway; macroautophagy; and positive regulation of autophagosome assembly. Located in phagophore assembly site. Is extrinsic component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ATG11 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (661137..664673, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanism of Atg9 recruitment by Atg11 in the cytoplasm-to-vacuole targeting pathway.
Title: Mechanism of Atg9 recruitment by Atg11 in the cytoplasm-to-vacuole targeting pathway.
Atg11-mediated activation of Atg1 kinase in fission yeast.
Title: Atg11-mediated activation of Atg1 kinase in fission yeast.
TORC1 inactivation stimulates autophagy of nucleoporin and nuclear pore complexes.
Title: TORC1 inactivation stimulates autophagy of nucleoporin and nuclear pore complexes.
The Third Coiled Coil Domain of Atg11 Is Required for Shaping Mitophagy Initiation Sites.
Title: The Third Coiled Coil Domain of Atg11 Is Required for Shaping Mitophagy Initiation Sites.
In yeast, Atg11 and Atg17 function as protein scaffolds, essential for selective and non-selective types of autophagy, respectively. [review]
Title: Mechanistic Insights into the Role of Atg11 in Selective Autophagy.
Data show that activated autophagy protein ATG11 (Atg11) dimerizes and tethers autophagy protein ATG9 (Atg9) vesicles.
Title: Atg11 tethers Atg9 vesicles to initiate selective autophagy.
Atg11 plays important roles in low-level nonselective autophagy
Title: Induction of autophagy by phosphate starvation in an Atg11-dependent manner in Saccharomyces cerevisiae.
In vitro studies show that Atg1 kinase is activated by selective autophagy targets in yeast requiring the Atg11 scaffold.
Title: Receptor-Bound Targets of Selective Autophagy Use a Scaffold Protein to Activate the Atg1 Kinase.
Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy initiation.
Title: Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy initiation.
Selective autophagy receptors interact with two proteins of the core autophagic machinery: the scaffold protein Atg11 and the ubiquitin-like protein Atg8.
Title: Phosphorylation of mitophagy and pexophagy receptors coordinates their interaction with Atg8 and Atg11.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables SNARE binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy of peroxisome	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to nitrogen starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cytoplasm to vacuole targeting by the Cvt pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cytoplasm to vacuole targeting by the Cvt pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pexophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in piecemeal microautophagy of the nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagosome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to phagophore assembly site	IDA Inferred from Direct Assay more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in reticulophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Atg1/ULK1 kinase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagophore assembly site	IDA Inferred from Direct Assay more info	PubMed
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: autophagy protein ATG11

NP_015374.1

Adapter protein for pexophagy and the Cvt targeting pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the PAS; recruits Dnm1p to facilitate fission of mitochondria that are destined for removal by mitophagy

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

661137..664673 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184146.1 → NP_015374.1 TPA: autophagy protein ATG11 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015374.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W457, Q12527

UniProtKB/TrEMBL

A0A8H4BUD9, B5VTK3, C8ZJ74, N1NVK0

Conserved Domains (2) summary

COG1196
Location:700 → 853

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam10377
Location:992 → 1171

ATG11; Autophagy-related protein 11