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    GPH1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856289, updated on 22-Aug-2024

    Summary

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    Official Symbol
    GPH1
    Primary source
    FungiDB:YPR160W
    Locus tag
    YPR160W
    See related
    SGD:S000006364; AllianceGenome:SGD:S000006364; VEuPathDB:YPR160W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glycogen phosphorylase activity. Involved in glycogen catabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease V; glycogen storage disease VI; and lactic acidosis. Orthologous to human PYGB (glycogen phosphorylase B); PYGL (glycogen phosphorylase L); and PYGM (glycogen phosphorylase, muscle associated). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (861306..864014)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene beta-glucan synthesis-associated protein KRE6 Neighboring gene uncharacterized protein Neighboring gene tRNA-Gly Neighboring gene cyclin-dependent serine/threonine protein kinase SGV1 Neighboring gene origin recognition complex subunit 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Yeast Mutant Deleted of GPH1 Bears Defects in Lipid Metabolism. Gsell M, et al. PLoS One, 2015. PMID 26327557, Free PMC Article
    2. Wine yeast strains engineered for glycogen overproduction display enhanced viability under glucose deprivation conditions. Pérez-Torrado R, et al. Appl Environ Microbiol, 2002 Jul. PMID 12089012, Free PMC Article
    3. A protein phosphorylation switch at the conserved allosteric site in GP. Lin K, et al. Science, 1996 Sep 13. PMID 8703213
    4. Parallel evolution in two homologues of phosphorylase. Rath VL, et al. Nat Struct Biol, 1994 Oct. PMID 7634071
    5. Mechanism of regulation in yeast glycogen phosphorylase. Lin K, et al. J Biol Chem, 1995 Nov 10. PMID 7592925

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pho85p controls the phosphorylation state of glycogen phosphorylase
      Title: Regulation of yeast glycogen phosphorylase by the cyclin-dependent protein kinase Pho85p.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 1,4-alpha-oligoglucan phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SHG alpha-glucan phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycogen phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycogen phosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycogen phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycogen phosphorylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables linear malto-oligosaccharide phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycogen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycogen phosphorylase
    NP_015486.1
    • Glycogen phosphorylase required for the mobilization of glycogen; non-essential; regulated by cyclic AMP-mediated phosphorylation; phosphorylation by Cdc28p may coordinately regulate carbohydrate metabolism and the cell cycle; expression is regulated by stress-response elements and by the HOG MAP kinase pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      861306..864014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184257.1 → NP_015486.1  TPA: glycogen phosphorylase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015486.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4G1, P06738
      UniProtKB/TrEMBL
      A6ZX36, C8ZJI4, G2WPX3, N1NVM0
      Conserved Domains (1) summary
      cd04300
      Location:68 → 898
      GT35_Glycogen_Phosphorylase; glycogen phosphorylase and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06738.4

    Gene LinkOut

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