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    PPT1 protein serine/threonine phosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853023, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PPT1
    Official Full Name
    protein serine/threonine phosphatase
    Primary source
    SGD:S000003355
    Locus tag
    YGR123C
    See related
    AllianceGenome:SGD:S000003355; FungiDB:YGR123C; VEuPathDB:YGR123C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein serine/threonine phosphatase activity. Involved in protein dephosphorylation. Located in cytoplasm and nucleus. Orthologous to human PPP5C (protein phosphatase 5 catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PPT1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (736662..738203, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-Arg Neighboring gene tRNA-Ile Neighboring gene asparagine synthase (glutamine-hydrolyzing) 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An 18.3 kb DNA fragment from yeast chromosome VII carries four unknown open reading frames, the gene for an Asn synthase, remnants of Ty and three tRNA genes. Van Dyck L, et al. Yeast, 1997 Feb. PMID 9046098
    2. Global analysis of phosphoproteome regulation by the Ser/Thr phosphatase Ppt1 in Saccharomyces cerevisiae. Schreiber TB, et al. J Proteome Res, 2012 Apr 6. PMID 22369663
    3. Characterization of Saccharomyces cerevisiae protein Ser/Thr phosphatase T1 and comparison to its mammalian homolog PP5. Jeong JY, et al. BMC Cell Biol, 2003 Mar 28. PMID 12694636, Free PMC Article
    4. Expression, purification and refolding of the phosphatase domain of protein phosphatase 1 (Ppt1) from Saccharomyces cerevisiae. Suhre MH, et al. Int J Biol Macromol, 2006 Aug 15. PMID 16442612
    5. Conformational switching of the molecular chaperone Hsp90 via regulated phosphorylation. Soroka J, et al. Mol Cell, 2012 Feb 24. PMID 22365831

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. finding show that regulation of the Hsf1 S608 phosphorylation status by reciprocal actions of CK2 and Ppt1 might play an important role to determine Hsf1 sensitivity towards ethanol stress
      Title: CK2-dependent inhibitory phosphorylation is relieved by Ppt1 phosphatase for the ethanol stress-specific activation of Hsf1 in Saccharomyces cerevisiae.
    2. Taken together, these data demonstrate that hyperphosphorylation of Hsf1p caused by loss of the PPT1 gene at least partly accounts for the defective stress response and high ethanol productivity of modern sake yeast strains.
      Title: Association of constitutive hyperphosphorylation of Hsf1p with a defective ethanol stress response in Saccharomyces cerevisiae sake yeast strains.
    3. The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90.
      Title: The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein serine/threonine phosphatase
    NP_011639.3
    • Protein serine/threonine phosphatase; regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      736662..738203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181252.3 → NP_011639.3  TPA: protein serine/threonine phosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011639.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUQ5, P53043
      UniProtKB/TrEMBL
      A6ZUD7, B3LIA5, B5VJ69, C7GUH2, C8Z916, N1P3Q7
      Conserved Domains (3) summary
      PLN03088
      Location:10 → 130
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:12 → 40
      TPR; TPR repeat [structural motif]
      cd07417
      Location:165 → 508
      MPP_PP5_C; PP5, C-terminal metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53043.1

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